Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl
Preferences help
Polish version English version Language
enabled [disable] Abstract
Number of results

Results found: 9

Number of results on page
first rewind previous Page / 1 next fast forward last

Search results

Search:
in the keywords:  Multiple sclerosis
help Sort By:

help Limit search:
first rewind previous Page / 1 next fast forward last
1
Content available remote

CSF and serum total-tau and phospho-tau(181P) in MS patients

100%
Jaworski J., Psujek M., Bartosik-Psujek H.
Open Medicine
|
2011
|
vol. 6
|
issue 2
193-200
EN
In search of biological marker in multiple sclerosis (MS), total-tau and phospho-tau (Thr181) concentrations were established in CSF and serum of 78 patients with MS, using commercially available kits. Serum and CSF concentrations of IgG, IgM, and albumin were assayed simultaneously to calculate quotients and indices of intrathecal synthesis. Serum t-tau detection was strikingly low (23.1%); therefore, this factor was excluded from further analysis. Serum p-tau levels did not correlate with any of indices or quotients. Unexpectedly, CSF t-tau and p-tau showed an inverse relation with MSSS and EDSS, which has not been published elsewhere. Our results do not support utility of serum t-tau and p-tau as surrogate markers for MS.
2
Content available remote

Annexin V antibodies in multiple sclerosis and SLE/APS

100%
Baleva M., Stoilova D., Shotekov P., Nikolov K.
Open Medicine
|
2013
|
vol. 8
|
issue 2
225-228
EN
Multiple sclerosis (MS) is an autoimmune disease with unclear etiopathogenesis. Some MS patients have anticardiolipin (ACL), anti-beta-2-glycoprotein-I (B2GPI) and anti-annexin V (AnV) antibodies. These antibodies can also be found in systemic lupus erythematosus with antiphospholipid syndrome (SLE/APS). The aim of our study was to compare the levels of ACL, B2GPI and AnV antibodies in MS and SLE/APS. Materials and methods: We investigated serum levels of IgG and IgM ACL, B2GPI and AnV in 21 MS patients, 30 SLE/APS patients and 30 controls using ELISA. Results: Mean levels of IgM and IgG ACL and B2GPI in MS were comparable with controls and lower than SLE/APS (p<0.05). Mean levels of IgM AnV in MS were higher compared to SLE/APS and controls (p<0.05); mean levels of IgG AnV in MS were higher than normal but similar to SLE/APS (p>0.05). Discussion: The results show that MS with negative “classic” autoantibodies (ACL and B2GPI) and without clinical data for antiphospholipid syndrome may have other positive antiphospholipid antibodies, such as AnV. Larger studies are needed to clarify whether AnV are epiphenomenon of the vascular and organ damage or they play a pathogenic role in the development of MS.
3
Publication available in full text mode
Content available

ESTIMATION OF POSTURAL STABILITY OF A PATIENT WITH MULTIPLE SCLEROSIS DURING A REHABILITATION PROGRAM - CASE STUDY

100%
BUTELSKA A., ZYZNAWSKA J., BOBER A., BĄK S., MAŃKO G.
Medicina Internacia Revuo
|
2013
|
vol. 25
|
issue 101
220- 229
EN
Background and purpose: Multiple sclerosis (MS) is a demyelinating disease, usually with multifocal symptoms and multiphasic course that is emerging as a result of inflammation and the formation of foci of myelin breakdown in the central nervous system as a consequence of not fully known harmful external factors. The aim of this study was to analyze the results of tests allowing to detect imbalances in patients with multiple sclerosis. Material and Methods: A 38 year old male with MS diagnosed in 2006 was examined. The study used three tests of balance: "Timed Up & Go" test, Tinetti test and Berg Balance Scale. The results of the scale were analyzed, which consisted in a variety of motor tasks assessing balance and gait. Tests were repeated every month for 10 months. Results: The results in each test over 10 months significantly change. Changes in response to the increase of the number of tasks and the difficulty of the test occured. As a consequence of impaired balance control, the number of falls increased. Conclusions: The stability of the patient with multiple sclerosis is getting worse in each test evaluated. The deficit of stability increased in response to increasing the number of tasks and increasing the difficulty of the test. A key role in postural stability in standing plays the pelvis and lumbo-pelvic-hip complex.
4
Content available remote

Anxiety and social activities in multiple sclerosis patients

100%
Leonavičius R., Adomaitienė V.
Open Medicine
|
2013
|
vol. 8
|
issue 1
56-61
EN
Despite that the prevalence of depression has been thoroughly analyzed in multiple sclerosis (MS) patients and affects approximately 15%–20% of the MS population, attention paid to social activities concomitant with anxiety is still too sporadic. The aim of this study was to find the prevalence of anxiety and social activities aggraded/aggravated with anxiety in the MS population in Lithuania and to analyze how it correlates with socio-demographic factors, clinical outcomes of MS and depression. Three hundred twelve MS patients took part in this study; anxiety prevalence was pointed in 20.2%. Only 23.4% of the study population was socially active. Our study shows a significant level of anxiety and low level of social activity in people with MS. Anxiety in MS patients was strongly related with younger age, shorter MS duration, prevalence of depression and lower level of social activity. A higher level of social activity was significantly related with older urban MS patients who indicated family status as living together and longer MS duration.
5
Content available remote

Impact of depression on multiple sclerosis patients

100%
Leonavičius R., Adomaitienė V.
Open Medicine
|
2012
|
vol. 7
|
issue 5
685-690
6
Content available remote

The relationships between depression and life activities and well-being of multiple sclerosis patients

88%
Leonavičius R., Adomaitienė V., Leskauskas D.
Open Medicine
|
2011
|
vol. 6
|
issue 5
652-661
EN
Multiple sclerosis (MS) is one of the most disabling neurodegenerative disorders. Depression is the most frequent psychiatric disorder accompanying MS. Although much attention is given to correlations between depression and MS clinical factors, analysis of correlations between depression and life activities (social, household, professional activities and family life) and the well-being of MS patients’ is insufficient. However, improvement of these functions could positively influence the outcomes of MS treatment. The aim of this study was to evaluate relationships between depression, life activities of MS patients, and their proposals how to improve the well-being. Materials and methods. The study lasted three years with 270 adult MS patients involved in it. ICD-10 criteria were used to diagnose depression. Original questionnaire was used to measure life activities and the well-being of the patients. Results. Prevalence of depression was 20.7% with no difference regarding the gender. Almost 84% of depressed respondents indicated, that MS disturbs their family life, 71.4% recommended to assign more attention to MS in general and 64.3% - to include more medications into reimbursement list. Conclusions. MS patients diagnosed with depression significantly more often than non-depressed indicate that MS disturbs their family life; recommend to assign more attention to MS in general and to include more medications into reimbursement list.
7
Content available remote

Acute abdomen due to bladder perforation in a patient with multiple sclerosis

88%
Habek D., Pavelić-Turudić T., Vukelić M., Mazul-Sunko B.
Open Medicine
|
2013
|
vol. 8
|
issue 3
362-363
EN
The authors presented a case report of the acute abdomen with pelvic abscess because bladder perforation in a 21-year-old patient with multiple sclerosis and intermittent catheterization of the urinary bladder.
8
Content available remote

Sympathetic nervous system and neurotransmitters: their possible role in neuroimmunomodulation of multiple sclerosis and some other autoimmune diseases

75%
Markelov V., Trushin M.
Open Medicine
|
2006
|
vol. 1
|
issue 4
313-329
EN
Multiple sclerosis is still a disease without a cure. Although intensive research efforts have led to the development of drugs that modify the activity of the disease, most of them have various side effects and are expensive. At the same time it is becoming apparent that some remedies usually used to treat somatic and psychic disorders also have immunomodulating properties, and may help manage multiple sclerosis and other autoimmune diseases. We describe here the role of the sympathetic nervous system in the neuro-immune interaction in multiple sclerosis and other immune diseases with increased cellular immunity as well as neurochemical disturbances that take place in these disorders.
9
Publication available in full text mode
Content available

REPRINT OF POLISH TRANSLATION OF ARTICLE BY ACCORD INTERNATIONAL ASSOCIATION FOR THE STUDY OF PAIN (IASP) - PAIN 154 (2013) 2691-2699 Migraine headaches and pain with neuropathic characteristics: Comorbid conditions in patients with multiple sclerosis

63%
Moisset X., Ouchchane L., Guy N., Bayle D. J., Dallel R., Clavelou P.
Ból
|
2014
|
vol. 15
|
issue 2
16-27
EN
We conducted a postal survey to assess the prevalence and characteristics of neuropathic pain and migraine in a cohort of multiple sclerosis (MS) patients. Of the 1300 questionnaires sent, 673 could be used for statistical analysis. Among the respondents, the overall pain prevalence in the previous month was 79%, with 51% experiencing pain with neuropathic characteristics (NCs) and 46% migraine. MS patients with both migraine and NC pain (32% of the respondents) reported more severe pain and had lower health-related quality of life than MS patients with either migraine or NC pain. Pain intensity in MS patients with migraine was moderate (6.0±0.1). Migraine was mostly episodic, but headaches were occurring on P15 days per month in 15% of those with migraine. MS patients with migraine were younger and had shorter disease durations than those with NC pain. NC pain was most often located in the extremities, back and head, and was frequently described as tingling and pins-and-needles. The intensity of NC pain was low to moderate (4.9±0.1), but positively correlated with the number of painful body sites. Nonetheless, patients with NC pain were more disabled (with a higher Expanded Disability Status Scale and pain interference index) than patients with migraine. Migraine, but not NC pain, was associated with age, disease duration, relapsing-remitting course, and interferon-beta treatment. This suggests that NC pain and migraine are mediated by different mechanisms. Therefore, pain mechanisms that specifically operate in MS patients need to be characterized to design optimal treatments for these individuals.
PL
Przeprowadziliśmy listowne badanie kwestionariuszowe w celu oceny częstości występowania i charakterystyki bólu neuropatycznego i migreny w kohorcie chorych na stwardnienie rozsiane (SR). Spośród wysłanych 1300 kwestionariuszy 673 nadawało się do analizy statystycznej. Ogólna częstość występowania bólu u respondentów w ciągu miesiąca poprzedzającego badanie wyniosła 79%; 51% badanych odczuwało ból o cechach neuropatycznych (BN), a 46% - ból migrenowy. Chorzy odczuwający zarówno ból migrenowy jak i BN (32% respondentów) zgłaszali większe natężenie bólu i gorszą jakość życia związaną ze stanem zdrowia niż pacjenci ze SR odczuwający tylko jeden z tych bólów. Natężenie bólu u chorych na SR i migrenę było umiarkowane (6,0±0,1). Migrena w większości przypadków miała charakter epizodyczny, ale u 15% osób z migreną bóle głowy występowały ≥15 dni w miesiącu. Chorzy na SR i na migrenę byli młodsi i chorowali krócej niż pacjenci z BN. Ból o charakterze neuropatycznym najczęściej umiejscowiony był w kończynach, plecach i głowie; często opisywany był jako mrowienie lub kłucie. Nasilenie BN było małe lub umiarkowane (4,9±0,1) ale korelowało z liczbą objętych bólem części ciała. Niemniej jednak pacjenci z BN byli bardziej niesprawni (mieli większą punktację w Expanded Disability Status Scale i w Pain Interference Index) niż pacjenci z migreną. W przeciwieństwie do BN, migrena była powiązana z wiekiem, czasem trwania choroby, postacią nawracająco-zwalniającą choroby oraz z leczeniem interferonem beta. Wskazuje to na odrębne mechanizmy BN i migreny. W związku z tym wydaje się konieczne scharakteryzowanie mechanizmów bólu, które działają swoiście u chorych na SR w celu opracowania optymalnego leczenia tych pacjentów.
first rewind previous Page / 1 next fast forward last
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.