Objective: In this study, our aim was to investigate whether Monocyte/HDL ratio is a marker of the prognosis of the idiopathic sudden hearing loss (ISHL). Study design: Retrospective, case-control clinical trial. Materials and Methods: 45 patients, who were diagnosed with idiopathic sudden hearing loss and were treated with the same therapy regime and 47 healthy volunteers, who applied to the hospital for routine controls and had audiological and laboratory examination between March 2014 and December 2015, were included in the study. Monocyte/HDL ratios of the patients in the study and control groups were calculated from the results of the blood counts and biochemical analysis. Additionally, the study group was divided into two sub-groups regarding their responses (responders and non-responders) to the treatment determined by the audiological examination, which was carried out after 3 months according to the Siegel criteria. The Monocyte/HDL ratios between the groups were statistically evaluated. Results: There was no statistically significant difference between the MHRs of the study and control groups (p=0.574). However, the MHR was significantly higher in the non-responders’ group compared with the responders’ group, although they were treated with the same therapy regimen (p=0.005). Conclusion: There was no difference in MHRs between study and control groups. However, as MHR was higher in the patients with good prognosis compared with the patients with bad prognosis, we believe that regarding the ISHL, MHR is not a predictive value but might have prognostic marker.
Objective: In this study, our aim was to investigate whether Monocyte/HDL ratio is a marker of the prognosis of the idiopathic sudden hearing loss (ISHL). Study design: Retrospective, case-control clinical trial. Materials and Methods: 45 patients, who were diagnosed with idiopathic sudden hearing loss and were treated with the same therapy regime and 47 healthy volunteers, who applied to the hospital for routine controls and had audiological and laboratory examination between March 2014 and December 2015, were included in the study. Monocyte/HDL ratios of the patients in the study and control groups were calculated from the results of the blood counts and biochemical analysis. Additionally, the study group was divided into two sub-groups regarding their responses (responders and non-responders) to the treatment determined by the audiological examination, which was carried out after 3 months according to the Siegel criteria. The Monocyte/HDL ratios between the groups were statistically evaluated. Results: There was no statistically significant difference between the MHRs of the study and control groups (p=0.574). However, the MHR was significantly higher in the non-responders’ group compared with the responders’ group, although they were treated with the same therapy regimen (p=0.005). Conclusion: There was no difference in MHRs between study and control groups. However, as MHR was higher in the patients with good prognosis compared with the patients with bad prognosis, we believe that regarding the ISHL, MHR is not a predictive value but might have prognostic marker.
Cel: Celem niniejszego badania było zbadanie związku, o ile on istnieje, między wartością MHR a idiopatycznym szumem usznym. Projekt badania: Prospektywne badanie kliniczno-kontrolne. Materiał i metody: Do badania włączono 89 pacjentów (grupa badana), u których od marca 2015 roku do czerwca 2016 roku w ambulatorium przyklinicznym zdiagnozowano idiopatyczne szumy uszne oraz 87 zdrowych osób, które zgłosiły się do szpitala w celu przeprowadzenia rutynowego badania lekarskiego i uzyskały prawidłowe wyniki badania audiometrycznego i otoskopowego (zdrowa grupa kontrolna). Próbki krwi pobierano od pacjentów podczas pierwszego badania. Współczynnik HDL (MHR – Monocyte/HDL rate) uzyskano przez prosty podział liczby monocytów przez poziom HDL. Współczynniki MHR uzyskane dla obu grup poddano analizie statystycznej. Wyniki: Liczba monocytów i wartość MHR były większe w grupie badanej, a poziom stężenia HDL był niższy w porównaniu z grupą kontrolną (p<0,05). W niniejszym badaniu wartość odcięcia dla MHR w odniesieniu do szumów usznych ustalono na 11. Wniosek: Współczynnik MHR okazał się wysoki u pacjentów z idiopatycznymi szumami usznymi. Uzyskany wynik wskazuje na udział zdarzeń miażdżycowych i stresu oksydacyjnego w etiologii szumów usznych.
Aim: The aim of this study was to evaluate the association between the monocyte/HDL ratio (MHR) and idiopathic tinnitus. Study Design: Retrospective case-control study. Material-method: Eighty-nine patients with idiopathic tinnitus diagnosed on an outpatient basis between March 2015 and June 2016 and 87 healthy individuals who presented to our hospital for a routine health examination and had normal audiometry and otoscopy results were included in the study. Blood samples were obtained from patients during the first examination. The MHR was calculated as the ratio of the monocyte count to the HDL level. MHR ratios were compared statistically between the groups. Results: The monocyte count and the MHR were higher and HDL was lower in the study group compared to the control group (p< 0.05). The cut-off value of MHR for diagnosing tinnitus was 11. Conclusion: The MHR ratio was high in patients with idiopathic tinnitus, which supports the fact that atherosclerotic events and oxidative stress are implicated in the etiology of tinnitus.
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