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Detecting a deletion in the coding region of the bovine bone morphogenetic protein 15 gene (BMP15)

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Zhang L.-P., Gan Q.-F., Zhang X.-H., Li H.-D., Hou G.-Y., Li Y.-J., Gao X., Ren H.-Y., Chen J. B., Xu S.-Z.

Journal of Applied Genetics

2009

vol. 50

issue 2

145-148

The aim of this study was to detect polymorphism in the bovine bone morphogenetic protein 15 (BMP15) gene. On the basis of PCR-SSCP and DNA sequencing, a 4-bp deletion was identified in the coding region of the gene. Sequence analysis revealed that the deletion altered the reading frame and introduced a stop codon at position 264. Eight breeds (Luxi, Qinchuan, Nanyang, Jinnan, Bohai Black, Menggolian, Holstein, and Simmental) were genotyped by PCR-SSCP. No cows homozygous for this mutation were observed in these breeds. Heterozygous cows were detected in Luxi, Qinchuan, Nanyang, Jinnan and Bohai Black cattle. Fecundity was not increased in heterozygous individuals.

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1 Journal of Applied Genetics

1 2009

1 Chen J. B.

1 Gan Q.-F.

1 Gao X.

1 Hou G.-Y.

1 Li H.-D.

1 Li Y.-J.

1 Ren H.-Y.

1 Xu S.-Z.

1 Zhang L.-P.

1 Zhang X.-H.

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Detecting a deletion in the coding region of the bovine bone morphogenetic protein 15 gene (BMP15)