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NADPH-diaphorase in the cat carotid body

100%

Walski M., Pokorski M.

Acta Neurobiologiae Experimentalis

2000

vol. 60

issue 1

41-48

Ultrastructural examinations of the CB showed that NOS-related NADPH-d activity is present in the chemoreceptor cells (Fig. 1A). The NADPH-d reaction product appeared as small, intense, dark particles scattered in the cytoplasm of the cells. The particles were distributed most densely or tended to aggregate in the perinuclear region, the endoplasmic reticulum channels, and in between the dense-core vesicles but not in the vesicles themselves. These particles were distinguishable from ribosomes from which they were larger and more electron dense. The particles were absent in the control specimens in which B-NADPH was omitted (Fig. 1B). The presence of NOS, which synthesizes a short-lived gaseous NO messenger, may have significant implications for the CB function. NO could not only affect the autonomic and sensory nerve endings but also be a direct participant of the chemoreceptor cell signaling process. The exact role of the nitergic pathway in the CB is unclear at present.

NANC transmission in intestines and its pharmacological modulation

88%

Bauer V.

Acta Neurobiologiae Experimentalis

1993

vol. 53

issue 1

65-77

Non-adrenergic, non-cholinergic (NANC) nerve stimulation results in excitation (e.j.p., rebound depolarization, contractions) or inhibition (i.j.p., afterhyperpolarization, relaxations) of the gut. NANC neuronal mechanisms participate in the maintenance of the basal tone and spontaneous activity of the gut. There are however species differencies, i.e. both NANC excitation and inhibition are present in the guinea pig and only NANC inhibition in the rat intestine. Substance P-like neuropeptide/s are suggested to be mediators released from excitatory NANC and sensory nerves. The latter are activated by histamine and degenerated by capsaicin. There is evidence in favor of a nitric oxide-like substance rather than ATP, dopamin, GABA and neuropeptides (e.g. VIP, PHI/PHM) as the inhibitory NANC mediator in the gut. TTX, high Mg?+ -low Ca?+ media, 3,4-diaminopyridine, dipyridamol and adenosine deaminase modulate NANC excitation and inhibition. The NANC excitation is more sensitive than the NANC inhibition to the action of catecholamines, reserpine, 6-hydroxydopamine, chymotrypsin, , bacitracin, opioids, free oxygen species and low concentration of local anesthetics.

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2 Acta Neurobiologiae Experimentalis

1 2000

1 1993

1 Bauer V.

1 Pokorski M.

1 Walski M.

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NADPH-diaphorase in the cat carotid body

NANC transmission in intestines and its pharmacological modulation