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Subfertile couple with t(4;22)(q23;q11.2)

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Srebniak M., Popowska L., Wawrzkiewicz-Witkowska A., Tomaszewska A., Kazmierczak W.
Journal of Applied Genetics
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2005
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vol. 46
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issue 3
333-336
EN
A couple was referred for cytogenetic examination due to idiopathic miscarriages. The proband proved to be a carrier of chromosomal translocation and her partner's karyotype was found to be normal. The karyotype of the proband is 46,XX,t(4;22)(q23;q11.2) and can be regarded as a reason of fertility problems in the investigated couple. The risk of further miscarriages is high, but the risk of a progeny with abnormal karyotype is rather low, as the progeny would probably have lethal imbalances.
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