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Role of the adaptins, dynamin-like GTP-ases and Rab proteins in metabolic disorders and various infections

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Kierczak M., Surmacz L., Wiejak J., Wyroba E.
Postępy Higieny i Medycyny Doświadczalnej
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2003
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vol. 57
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issue 6
727-737
EN
Numerous metabolic and genetic diseases are due to mutations in adaptins, dynamin-like GTP-ases or disorders in trafficking machinery mediated by Rab proteins. A great number of pathogenes including viruses (HIV, SIV), bacteria and protozoa use various elements of endocytic/trafficking machinery to get into the host cells and to make their infection successful. Their different strategies are discussed.
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