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The effect of angiotensin II and its fragments on post-alcohol impairment of learning and memory

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Wisniewski K., Borawska M., Car H.
Polish Journal of Pharmacology
|
1993
|
vol. 45
|
issue 1
23-29
EN
Angiotensin II (1-8) (A II) and its fragments: angiotensin III (2-8) (A III), angiotensin IV (3-8) (A IV), angiotensin V (4-8) (A V) and angiotensin VI (3-7) (A VI) accelerate acquisition of avoidance response and prolong their extinction. A II fragments are devoid classical A II activities such as the effects on blood pressure and thirst. Alcohol administered chronically (for 9 weeks) depresses the ability to retrieve and acquire avoidance responses. The investigated A II fragments counteract the post-alcohol impairment of learning and memory processes (A V being somewhat less active). Fragments A IV and A VI normalize the retrieval in offspring of mothers exposed to alcohol pre- and post-natally.
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