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1

GMO -innovative biotechnology in 21st century medicine

100%
Twardowski T.
Biotechnologia
|
2009
|
issue 5
5-10
EN
Genetically modified organisms are the key step for innovative medicines. The innovative drugs in the 21st century will be in the majority of proteins, nucleic acids and their combinations. The critical issues in case of biopharmaceuticals are quality and reproducibility of production. These aspects are evident in biosimilars (generics) and protection of intellectual property rights.
2

Personalised medicine and its role in new drugs development

100%
Schmitt C., Stencel D.
Biotechnologia
|
2009
|
issue 5
84-87
EN
Personalized medicine is coming step by step to real clinical practice. The new era is forthcoming, in which 'one size does not fit all'. The hopes and expectations predominantly are based on achievements of molecular biology. Close connection between therapy and corresponding diagnostic test can lead to better defining patients target groups. Moreover, biomarkers defining is becoming a new approach to therapy stratification. Viral, oncologic, inflammatory and metabolic diseases are the examples of Roche involvement in this strategic way of development.
3

Is investment in personalized medicine worthwhile?

100%
Nowakowska E., Matschay A., Metelska J., Burda K., Czubak A., Kus K.
Biotechnologia
|
2009
|
issue 5
84-87
EN
Since the dawn of the 21st century, pharmacology has become a field increasingly closely related to the development of a new science - genomics. Due to increasingly smaller efficacy of using 'conventional' therapies, the world of science is starting to seek drugs dedicated to patients with a specific genotype. The possibility of finding the genetic background of diseases largely incurable to this date, such as cancers, diabetes or depression, will allow for ?targeted therapy', improving thereby therapy efficacy by adjusting optimum treatment agents to the individual genetic profile of a specific patient. With propagation of this new type of medicine ? personalized medicine, the approach to therapy and the attitude of the patient himself are changing, as the patient seeing efficacy of his therapy is more willing to closely cooperate with the managing physician. Considerations discussed therein allow for a conclusion that further pharmacogenetic research is necessary not only to improve therapy efficacy, but also to seek possibilities of reasonable cost savings in medicine.
4

Biotechnology and intellectual property ? biosimilars and generics

100%
Twardowska A., Twardowski T.
Biotechnologia
|
2009
|
issue 5
75-83
EN
Patents are of critical value for future commercial development of innovation. Knowledge of legal system dedicated for intellectual property rights is limited. Basic information concerning biotechnological invention and patenting are presented with focus on 'red' biotechnology.
5

Personalized medicine from the perspective of oncologist

100%
Wysocki P. J., Handshuh P., Mackiewicz A.
Biotechnologia
|
2009
|
issue 5
18-26
EN
Personalized medicine is becoming very important in oncology. New achievements in genomics, molecular biology, toxicology or immunology lead to optimization and personalization of systemic therapy in cancer patients. Breast cancer is an excellent example for which personalized medicine is a real breakthrough in oncology. Targeted molecular therapies have significantly increased cancer patients' benefits and reduced adverse effects of the treatment. A large number of new promising anti-cancer agents and genomic tests are currently being tested in clinical trials. Results of the early clinical trails (Phase I and II) are very promising and provide a real hope for the fast progress of personalized oncology development.
6

Perfluorochemicals as liquid vectors of respiratotory gases used in medicine and biotechnology

88%
Pilarek M., Szewczyk K. W.
Biotechnologia
|
2005
|
issue 2
125-150
EN
Perfluorochemicals (fluorocarbons, PFCs) are the ones possible to use oxygen vector in biomedical sciences. Their structure, chemical and physical properties are fully described. The use of PFCs in medicine and biotechnology is presented. Possible areas of application of perfluorochemicals in biochemical engineering are discussed. Pure liquid or emulsified PFCs are used in the bioreactor cultures of microbial, plant or animal cells to improve the oxygen (or carbon dioxide) delivery with simultaneous reduction of hydrodynamic shear stress.
7

Biopharmaceuticals- a basic tool of modern pharmacotherapy

75%
Kaliszan R., Dlugokecka J.
|
EN
Current status of innovative drug industry is briefly presented with emphasis on new biopharmaceuticals introduced in the years 1995-2007. Adverse effects and problems of safety and effectiveness of these pharmacotherapeutics are reviewed. A separate part of the manuscript is devoted to the newly introduced methods of molecular diagnostics based on pharmacogenomics and employed in personalized medicine. Theranostic approach consisting in a joint use of drugs and companion diagnostics are characterized.
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