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ASSESSMENTS OF ANTIOXIDANT CONTENT AND THE ANTI-CARCINOGENIC EFFECT OF EXTRACTS OF SOLANUM ROSTRATUM DUNAL IN HUMAN CANCER CELLS

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Valadez Vega M. d. C., Izquierdo Vega J. A., Villagómez Ibarra J. R., Sánchez Gutiérrez M., Madrigal Santillán E. O., Morales Gonzalez J. A., Bautista Ávila M., García Velasco L.
Acta Poloniae Pharmaceutica - Drug Research
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2019
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vol. 76
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issue 3
493-502
EN
In Mexico, Solanum rostratum has been employed for the treatment of several diseases, including uterine cancer. The aim of this study was to evaluate the antioxidant and anti-carcinogenic activity of extracts of Solanum rostratum Dunal on MDA and SiHa cell lines. The methanolic, ethyl acetate, and hexane extracts of the aerial parts of Solanum rostratum were tested for phenols concentration, antioxidant activity, and anti-carcinogenic effect. The leaves extracts showed the highest content of phenols; however the flower-fruits extracts showed higher scavenging activity. On the other hand, ethyl acetate extracts exhibited the highest anti-carcinogenic effect, while methanolic extracts showed the least effect. The results of this work indicated that Solanum rostratum is a promising source of antioxidants, and the extracts exert a dose-dependent anti-carcinogenic effect on both cell lines.
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