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Mesenchymal stromal cells: tissue engineers and immune response modulators

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van_ d. B. L. C. J., Figdor C. G., Torensma R.
Archivum Immunologiae et Therapiae Experimentalis
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2008
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vol. 56
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issue 5
325-329
EN
Mesenchymal stromal cells (MSCs) show significant immune-suppressive properties both in vitro and in vivo. Based on their immune-stealth properties, allogeneic MSCs are used to treat several diseases, for example the injection of MSCs in infarcted heart tissue or their use in bone-cartilage regeneration. The most spectacular treatment was recently described. MSCs were able to down-regulate the severity of graft-versus-host disease, leading to an impressive 20 to 50% increase in the two-year survival of bone marrow transplantation patients. Here the current literature is reviewed to elucidate the different mechanisms involved in these two clinical treatment modalities of MSCs.
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