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A de novo interstitial 6q deletion in a boy with a split hand malformation

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Duran-Gonzalez J., Gutierrez-Angulo M., Garcia-Cruz D., Ayala M. L., Padilla M., Davalos I. P.

Journal of Applied Genetics

2007

vol. 48

issue 4

405-407

We report on a de novo interstitial deletion of (6)(q15q22.2) in a 5-year-old boy with developmental delay, microcephaly, facial dysmorphism, cryptorchidism, congenital heart defect, and split-hand malformation. Previous reports and this patient suggest that 6q21 may contain a gene or genes related either directly or indirectly to limb development.

Malformations of angiogenesis in the low differentiated human carcinomas. Immunohistochemical study

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Zoltowska A., Stepinski J., Lewko B., Zamorska B., Roszkiewicz A., Serkies K., Kruszewski W.

Archivum Immunologiae et Therapiae Experimentalis

2001

vol. 49

issue 1

59-62

Our previous observations showed that the perivascular mesenchyma of the thin-walled vessels (capillaries) in cancers may be the source of organ-specific stem cells. We suggested that the cells forming vascular channels in altered stroma participate in the tumor development. This study was designed to examine the distribution of the vessels and their appearance in the breast, lung and colon cancers. Using immunohistochemical methods, we have shown that in the low differentiated tumors both CD31 and factor VIII antigens may be expressed in capillaries chiefly on the periphery of neoplastic foci. Many of these vessels were discontinuous, with interruptions or unformed tubules. Sporadically, CD31 protein and factor VIII antigens were not expressed in capillaries inside the very low differentiated cancer cases. It is difficult to assess by immunohistochemichal means whether the vascular malformations are the primary or secondary phenomena in the malignancy and why these abnormalities were especially visible in some low differentiated cancers.

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1 Archivum Immunologiae et Therapiae Experimentalis

1 Journal of Applied Genetics

1 2007

1 2001

1 Ayala M. L.

1 Davalos I. P.

1 Duran-Gonzalez J.

1 Garcia-Cruz D.

1 Gutierrez-Angulo M.

1 Kruszewski W.

1 Lewko B.

1 Padilla M.

1 Roszkiewicz A.

1 Serkies K.

1 Stepinski J.

1 Zamorska B.

1 Zoltowska A.

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A de novo interstitial 6q deletion in a boy with a split hand malformation

Malformations of angiogenesis in the low differentiated human carcinomas. Immunohistochemical study