Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl
Preferences help
Polish version English version Language
enabled [disable] Abstract
Number of results

Results found: 2

Number of results on page
first rewind previous Page / 1 next fast forward last

Search results

Search:
in the keywords:  LDL
help Sort By:

help Limit search:
first rewind previous Page / 1 next fast forward last
1
Content available remote

Body Fat Deposition and Risk Factors of Cardiovascular Diseases in Men

100%
Fátima Glaner M., Alves Lima W., Borysiuk Z.
Human Movement
|
2010
|
vol. 11
|
issue 1
45-50
EN
Purpose. To determine whether risk factors for cardiovascular diseases (anthropometry, blood pressure, blood lipid profile) differ between men classified into the three relative body fat %BF categories (%BF ≤ 19: healthy; %BF>19 and %BF<30: overweight, and %BF ≥ 30: obesity).Basic procedures. A total of 112 volunteers from Brasília, Brazil, were submitted to the measurement of body weight, height and waist, abdominal and hip circumference. The body mass index (BMI) and waist-to-hip ratio (WHR) were calculated. %BF and body fat topography (arm, leg and trunk %BF) were estimated by dual-energy X-ray absorptiometry (DXA). Blood pressure was measured by auscultation and blood variables were determined by an enzymatic method. Univariate analysis of variance, one-way analysis of variance and the Scheffé post hoc test were used for statistical analysis (p<0.05).Main findings. The three %BF groups differed significantly in terms of body weight and body circumference measures, with higher mean values being observed the higher the %BF. Fasting glycemia and high-density lipoprotein did not differ between groups, indicating the interference of other factors. BMI, WHR, blood pressure, total cholesterol, low-density lipoprotein, triglycerides, atherogenic index and atherogenic cholesterol were statistically similar in the overweight and obese groups and differed significantly from the healthy group.Conclusions. Abdominal, waist, hip circumference and body fat topography (arm, leg and trunk %BF) differ between the three %BF groups. None of the blood variables differed significantly between the overweight and obese groups. The cutoff %BF>19 (measured by DXA) seems to be a good parameter to indicate cardiovascular risk factors in men.
2
Content available remote

Influence of elastin-derived peptides, glucose, LDL and oxLDL on nitric oxide synthase expression in human umbilical artery endothelial cells

84%
Garczorz W., Francuz T., Gmiński J., Likus W., Siemianowicz K., Jurczak T., Strzałka-Mrozik B.
|
2011
|
vol. 58
|
issue 3
375-379
EN
Endothelial dysfunction plays an important role in the development of atherosclerosis. Elastin-derived peptides (EDP), hyperglycemia, hypercholesterolemia and oxidized LDL have a proven proatherosclerotic potential. Nitric oxide generated by endothelial nitric oxide synthase (eNOS; EC 1.14.13.39) is an important vasorelaxant. Here we studied the influence of those proatherosclerotic factors on eNOS gene and protein expression in artery-derived endothelial cells. Human umbilical artery endothelial cells (HUAEC) were incubated with or without: glucose (270 mg/dl), LDL (200 mg/dl), oxidized LDL (oxLDL 25 mg/dl) or κ-elastin (0.5 and 2.5 µg/ml). Gene expression was assessed by real time RT-PCR, whilst the eNOS protein by ELISA. In cells incubated with 2.5 µg/ml of κ-elastin, a 31 % increase of eNOS mRNA expression was observed, but the protein level remained unchanged. OxLDL, LDL and glucose decreased the eNOS protein level by 74 %, 37 % and 29 %, respectively. OxLDL decreased eNOS mRNA by 42 %. LDL non-significantly decreased eNOS mRNA expression. An elevated glucose level did not affect the eNOS mRNA expression. Hyperglycemia and an elevated level of LDL, particularly oxLDL, decreased the level of eNOS protein in endothelial cells. As κ-elastin did not decrease the expression of eNOS gene in HUAEC, the proatherogenic properties of elastin-derived peptides are unlikely to be due to their influence on eNOS.
first rewind previous Page / 1 next fast forward last
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.