Search results

Search:
in the keywords: L-GLUTAMATE

Sort By:

Limit search:

Glutamate receptor-driven gene expression in learning

100%

Kaczmarek L.

Acta Neurobiologiae Experimentalis

1993

vol. 53

issue 1

187-196

The role of protein biosynthesis and ene expression in learning has been well documented. Similarly, the role of activation of glutamate receptors in neuronal plasticity have been shown repeatedly. In our studies we found that L-glutamate, acting through different kinds of its receptors may stimulate expression of c-fos and other genes encoding components of transcroption factors both in vivo and in vitro. We have also documented elevated expression of c-fos after induction of long lasting long term potentiation and variaous forms of behavioral training. In this paper these data are reviewed and a hypothesis, suggesting that neuronal nuclei may act as information integration device in memory formation is proposed.

Excitatory amino acids: physiological and pharmacological probes for neuroscience research

88%

Shinozaki H., Ishida M.

Acta Neurobiologiae Experimentalis

1993

vol. 53

issue 1

43-51

The 2S, 3S, 4S-isomer (L-CCG-I) of 2-(carboxycyclopropyl)glycine (CCG) is a potent metabotropic glutamate receptor agonist. L-CCG-I depressed monosynaptic excitation in the newborn rat spinal motoneurone at low concentrations well below those causing postsynaptic depolarization. 2S,3R,4S-CCG (L-CCG-IV) is a potent N-methyl-D-aspartate (NMDA)-type agonist. In cultured rat hippocampal neurones, L-CCG-IV caused marked increase in intracellular Ca?+ concentrations. 6-Carboxylated L-CCG-IV (DCG-IV), which is a tricarboxylated CCG derivative containing both chemical moieties of L-CCG-I and L-CCG-IV, depressed preferentially monosynaptic excitation of spinal reflexes in lower concentrations than L-CCG-I. 4-(2-Methoxyphenyl)-2-carboxy-3-pyrrolidineacetic acid (MEPA), which is the most potent kainoid yet described, is superior to acromelic acid A in causing depolarization of the newborn rat spinal motoneurone. In addition to MFPA, some non-kainoids demonstrated considerably high depolarizing activities. These new compounds would provide useful probes for neuroscience research.

Refine search results

2 Acta Neurobiologiae Experimentalis

2 1993

1 Ishida M.

1 Kaczmarek L.

1 Shinozaki H.

Search results

Glutamate receptor-driven gene expression in learning

Excitatory amino acids: physiological and pharmacological probes for neuroscience research