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THE INVESTIGATION OF PHYSICOCHEMICAL PROPERTIES OF THE SOLID DISPERSIONS IN THE PRESENCE POLYMERIC CARRIER- CHITOSAN

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Grimling B., Meler J., Pluta J., Górniak A.
Progress on Chemistry and Application of Chitin and its Derivatives
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2013
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vol. 18
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issue 18
167-173
EN
The BCS class II includes drugs with low solubility and high permeability.. Fenofibrate is an example of this class drugs. The aim of the study was to investigate the effect of chitosan on the saturation solubility of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in solid dispersions using a method of the solvent evaporation and physical mixtures at the drug to polymer ratio of 1:9,3:7,5:5.Solid dispersion of fenofibrate containing different ratio of medium and high molecular weight chitosan showed high saturation solubility compared to pure sample of drug. IR spectroscopy reveals that there was no chemical interaction between drug and the polymer. DSC studies showed that there is no change in the crystal structure of drug during the solid dispersion technique. Chitosan has been proposed as a useful excipient for enhancing the bioavailability of poorly water-soluble compounds.
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