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The role of free radicals in pathogenesis of the insulin dependent diabetes mellitus (IDDM)

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Komosinska K., Olczyk K.
Postępy Higieny i Medycyny Doświadczalnej
|
1995
|
vol. 49
|
issue 6
733-746
EN
The role of free radicals as well as cytokines (IL-1, tumor necrosis factor alpha, interferon gamma) and nitric oxide in the immune-mediated processes leading to the beta-cell destruction during IDDM is described.It is also pointed that the excess of IL-1ra in relation to IL-1 prevents IL-1 toxicity to beta-cells.
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