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  1. 1 Folia Biologica

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  1. 1 1995

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  1. 1 Mazur L.

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Frequency of micronuclei in mouse peropheral erythrocytes following WR -2721 application and X-irradiation

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Mazur L.
Folia Biologica
|
1995
|
vol. 43
|
issue 3-4
111-114
EN
The grequency of micronucleated polychromatic erythrocytes (MNPCEs) in the mouse peripheral bloos was assessed after WR-2721 (S-2-/3-aminopropylamino/ethylphosphorothioic acid) application and X-irradiation.The genotoxic was demonstratred for X-rays and WR-2721, as well as a protective effect of the thiol drug against X-ray-induced genotoxicity in the erythropoietic system.After X-irradiation of the mice, the number of MNPCEs was distincly increased.WR-2721 administration prior to X-irradiation resulted in a reduction of the X-ray- induced rise in the frequency of micronuclei.WR-2721 given alone, without subsequent X-irradiation, increased the number of MNPCES.The genotoxic and radioprotective effect of WR-2721 depended on the dose applied and the time interval between the thiol agent treatment and exposure of the mice to X-rays.
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