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1

Tioredoxin reductase ? a new target for molecular medical investigations

100%
Zagrodzki P.
Postępy Higieny i Medycyny Doświadczalnej
|
2002
|
vol. 56
|
issue 2
155-167
EN
Thioredoxin reductase (TrxR) is the first selenoenzyme containing selenocysteine in the active center and FAD as a second prosthetic group. TrxR catalyses the NADPH-dependent reduction of tioredoxin and of many other physiologically important substrates. TrxR exhibits many-fold increased activity in tumor cells and stimulates their proliferation as well the phenotype changes. Some gold compounds and a number of other clinically and experimentally used drugs have been shown to inhibit TrxR. The involvement of TrxR/Trx/NADPH system in broad spectrum of cellular processes renders it potential target for therapeutic approaches.
2

In ovo technology ? a tool modern prophylactic in poultry

75%
Bednarczyk M., Brzezinska J., Slawinska A., Siwek M., Urbanowski M., Kasperczyk K.
Biotechnologia
|
2010
|
issue 1
109-118
EN
Bird (chick) embryonic development takes place within the egg ? in ovo, outside its mother's body, making the embryo readily accessible to intervention, through the window which is cut in the eggshell. This fact was initially used for elaboration of in ovo embryo vaccination technology. Advances in animal biotechnology suggest several novel approaches that may be applied to in ovo technology, including for example: stimulation of beneficial bacterial profile in the colon of chicken, stimulation of immunological response, stimulation of embryonic development, theratogenic effects testing, selection for sexual phenotype, injection of genetically modified cells, etc. The use of feed additions such as prebiotics and probiotics or their combination- synbiotics influences health and chicken performance. Their administration in ovo could have an advantageous impact on an early development of immunological system in broiler chickens. In this overview, the new possibilities for practical use of the above-mentioned additions administrated by in ovo technology were presented.
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