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1

Circulating immune complexes in advanced Hodgkin's disease: qualitative analysis and prognostic significance

100%
Tomasevic Z., Jelic S.
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vol. 48
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issue 3
195-200
EN
The level of circulating immune complexes (CIC) may be a reflection of the underlying malignancy and appears to be related to the stage of disease, tumor burden and prognosis. Prognostic factors at diagnosis, clinical response, survival and CIC were analyzed in 89 patients with Hodgkin's disease. All patients were newly diagnosed, in advanced stage and treated with MOPP regimen. The median follow-up was 41 months. CIC were estimated by the polyethylene glycol precipitation test. The median age was 40 years and 52% were under the age of 45. Nodular sclerosis and mixed cellularity were the most common histologies, 36 and 35% respectively. ?B? symptoms were present in 65%, bulky disease in 29% and bone marrow involvement in 4% of the total. The erythrocyte sedimentation rate (ESR) was over 30 in 72% of patients and 27% had one or two extranodal localizations. Complete remission (CR) was obtained in 69 patients (77%). The only factor influencing the CR rate was the number of extranodal localizations (p<0.05). The ten-year relapse-free survival (RFS) and overall survival (OS) were 63 and 83%, respectively. RFS was adversely influenced by lymphocyte depletion histology (p=0.009) and by performance status over 1 (p=0. 003). Elevated CIC levels were detected in 58% of the total. Patients with ESR over 30 had significantly higher values of CIC (p<0. 05). Qualitative analysis of the CIC showed high levels of positivity to immunoglobulin G and M. C-reactive protein (CRP) was identified in 42% of all samples. CRP is an acute phase protein which shows conformational similarity to the immunoglobulin molecule. There were no significant correlations between levels of CIC and the other prognostic factors. Survival was not influenced by the CIC level.
2

Human sera with precipitating antibodies to human soluble immune complexes. A brief communication

80%
Milgrom F., Czechowski D.
Archivum Immunologiae et Therapiae Experimentalis
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2004
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vol. 52
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issue 3
197-200
EN
Previous numerous papers by the senior author dealt with the human serum factor referred to as anti-antibody which is specifically directed against IgG antibodies that underwent molecular transformation in the course of the reactions with their corresponding antigens. The reactions of this serum factor could be conveniently detected by means of agglutination of Rh-positive erythrocytes sensitized by anti Rh antibodies. No precipitation tests could be developed.Most studies were conducted by means of double diffusion in gel precipitation. Most studies were conducted by means of double diffusion in gel precipitation.Sera with precipitating anti-antibodies may serve as exquisite reagents for detection of soluble immune complexes in human sera.
3

Pre-operative levels of serum immunoglobulins, circulating immune complexes and complement proteins in patients with different types of neoplasms

80%
Gendek-Kubiak H., Grzegorczyk J., Gendek E. G., Kowalski M. L., Berner J.
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EN
In the sera of 30 neoplasm patients without metastases, the average IgG level was higher than in the control group (CG) (18.16 + 5.10 versus 12.62 + 2.14 g/l or 12.22 + 2.14 after excluding an out-lier). Average concentrations of CIC, IgM, C1i, C3c and C4 did not statistically differ between the groups. Dividing the patients' group into breast or ovary cancer (BC), melanoma (M), digestive tract cancer (DT) and other neoplasms (ON) subgroups revealed that the IgG increase did not apply to the BC group. Relatively decreased CIC concentrations in the BC and DT group and an increased C1i in the DT group were found. Several diversities detected in the humoral immunity indices' distributions and correlations suggest activation of different mechanisms depending on the neoplasm types.
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