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Serum metal evaluation in a small cohort of Amyotrophic Lateral Sclerosis patients reveals high levels of thiophylic species

100%
De Benedetti S., Lucchini G., Marocchi A., Penco S., Lunetta C., Iametti S., Gianazza E., Bonomi F.
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vol. 2
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issue 1
EN
Amyotrophic Lateral Sclerosis (ALS) has often been associated with improper/altered metal metabolism. Analysis of thiophylic metals in serum from a small and geographically restricted cohort of ALS patients indicates contents of Pb and Ni much higher in patients than in controls (Ni, 5-fold; Pb, 2-fold). Se levels are also higher in the patients’ group, which has instead lower As levels than controls. Thiophylic metals may impair biogenesis of FeS clusters or substitute for iron, even in folded proteins; Se may non-functionally replace S. Thus, improper assembly/ function of FeS proteins could represent another possible issue to be considered in ALS pathogenesis.
2
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Toxic elements content in PM10 samples from a coastal area of the Northern Adriatic Sea

88%
Cozzi F., Adami G., Barbieri P., Reisenhofer E., Apostoli P., Bovenzi M.
Open Chemistry
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2010
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vol. 8
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issue 5
1014-1026
EN
PM10 samples were collected during winter and summer seasons at two different sites in the area of Trieste (Italy). The content of As, Cd, Cr, Mn, Ni, Pb and V in the PM10 samples was determined by inductively coupled plasma-mass spectrometry, with the purpose of evaluating the relevance of PM10 inhalation as a route of human exposure to these elements. The results showed that the ambient air concentration of the aforementioned elements were below the limits or target values for both sites and season. Site and season-specific correlation analysis was conducted for the identification of metals with similar origin: very good correlation for the couple Ni-V was found in both sites and seasons, showing the influence of combustion of heavy oils in PM10 composition. The inter-site and seasonal variability of both PM10 and metal concentrations were examined. A stronger impact by the vehicular traffic on the PM10 and metal concentrations was found for the urban site in both seasons. Because of the great importance of the “Bora” wind on the local climate, variability of PM10 and toxic elements concentration with wind were analysed, allowing determination of the effect of wind on dilution of the pollutants for the urban site during both seasons. [...]
3
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Examination of distribution of trace elements in hair, fingernails and toenails as alternative biological materials. Application of chemometric methods

75%
Przybylowicz A., Chesy P., Herman M., Parczewski A., Walas S., Piekoszewski W.
Open Chemistry
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2012
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vol. 10
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issue 5
1590-1599
EN
The aim of this study was to find correlations between several studied elements and analyzed materials as well as the application and validation of an analytical method to determine trace elements in hair, fingernails and toenails of healthy volunteers (normal concentration). The method developed covers washing, mineralization and ICP-MS determination of 10 elements (Ca, Cd, Co, Cr, Cu, Fe, Mg, Ni, Pb and Zn) in hair and nails. Concentrations of the selected elements in hair, fingernails and toenails were measured for 24 women and 18 men. Furthermore, a chemometric approach (Principal Component Analysis, PCA) was employed to evaluate the correlations between concentrations of the elements in hair and nails and between these materials. Until now PCA has not been frequently applied in handling and interpretation of the results of analysis of biological materials. However, the results of the present investigation show the high potential of PCA in extraction of valuable information from analytical measurements. Additionally, PCA has become a useful tool for visualization of the obtained results. Moreover, the cluster analysis (CA) was used to group the samples according to gender, taking into account two different groups of elements: essential and toxic. [...]
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