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A five-year disease-free survival after combined hepatectomy and radiofrequency ablation of large hepatocellular carcinoma adjacent to vena cava

100%
Julianov A., Rachkov I., Karashmalakov A.
Open Medicine
|
2008
|
vol. 3
|
issue 3
370-373
EN
Destroying the hepatic tumor located close to the large vessels is a major limiting factor of radiofrequency ablation (RFA) that is difficult to overcome. A long-term disease-free survival after combined hepatectomy and radiofrequency ablation of a large hepatic tumor adjacent to vena cava has not been previously published. We report a patient with a 23-cm large hepatocellular carcinoma occupying the left lateral segments and a 6-cm contralateral intrahepatic metastasis in Couinaud segments VII–VIII adjacent to the retrohepatic IVC, treated with a combination of resection of the larger tumor and intraoperative radiofrequency ablation of the paracaval tumor under intermittent total vascular exclusion of the right hemiliver. After five years of follow up the patient is disease free. This case demonstrates the importance of vascular control for eliminating the heat sink effect of caval blood flow during RFA of liver tumors adjacent to inferior vena cava.
2
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Gallbladder actinomycosis: Is it a complication after radiofrequency ablation with transarterial chemoembolization for hepatocellular carcinoma?

88%
Han H., Choi S., Kim W., Song T., Choi S.
Open Medicine
|
2011
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vol. 6
|
issue 3
300-304
EN
A 64-year-old man with a history of gallstones, common bile duct stones, chronic hepatitis B virus infection, and hepatic cirrhosis with a Child-Pugh score B was satisfactorily treated for hepatocellular carcinoma with radiofrequency ablation and transarterial chemoembolization. His course, however, was complicated by gallbladder actinomycosis 14 months after treatment, resulting in acute cholecystitis. Such a chain of events suggests that gallbladder actinomycosis may develop after radiofrequency ablation and transarterial chemoembolization in patients who are known to have gallstones and that asymptomatic gallstones should be treated before the application of nonsurgical, but invasive procedures for hepatocellular carcinoma.
3
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Biochemical and molecular evidences for the antitumor potential of Ginkgo biloba leaves extract in rodents

63%
Ahmed H., Shousha W., El-Mezayen H., El-Toumy S., Sayed A., Ramadan A.
|
2017
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vol. 64
|
issue 1
25-33
EN
Hepatocellular carcinoma (HCC) is one of the deadliest primary cancers, with a 5-year survival rate of 10% or less. This study was undertaken to elucidate the underlying biochemical and molecular mechanisms in favor of N-nitrosodiethylamine-induced hepatocellular carcinoma. Furthermore, the aim of this work was extended to explore the efficacy of Ginkgo biloba leaves extract in deterioration of HCC in rats. In the current study, HCC group experienced significant downregulation of ING-3 gene expression and upregulation of Foxp-1 gene expression in liver. Treatment of HCC groups with Ginkgo biloba leaves extract resulted in upregulation of ING-3 and downregulation of Foxp-1 gene expression in liver. In addition, there was significant increase in serum alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA) and glypican-3 (GPC-3) levels in HCC group versus the negative control group. In contrast, the groups with HCC subjected to either high or low dose of Ginkgo biloba leaves extract elicited significant reduction (P<0.05) of AFP, CEA and GPC-3 in serum compared to the untreated HCC rats. Besides, histological examination of liver tissue sections of rats in HCC group revealed typical anaplasia. Interestingly, treatment with Ginkgo biloba leaves extract elicited marked improvement in the histological feature of liver tissue in HCC groups. In conclusion, this research indicated that the carcinogenic potency of N-nitrosodiethylamine targeted multiple systems on the cellular and molecular levels. In addition, the results of the current study shed light on the promising anticancer activity of Ginkgo biloba leaves extract in treatment of hepatocellular carcinoma induced chemically in the experimental model through its apoptotic and antiproliferative properties.
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