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Inhibition of the helicase activity of HCV NTPase/helicase by 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide-5'-triphosphate (ribavirin-TP).

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Borowski P., Lang M., Niebuhr A., Haag A., Schmitz H., Wiesch J. S. z., Choe J., Siwecka M. A., Kulikowski T.

2001

vol. 48

issue 3

739-744

In the presented study the ribavirin-TP - an established inhibitor of the NTPase activity of the superfamily NTPase/helicases II - was investigated as an inhibitor of the unwinding activity of the hepatitis C virus (HCV) NTPase/helicase. The kinetics of the reaction revealed that ribavirin-TP reduces the turnover number of the helicase reaction by a mechanism that does not correspond to that of the inhibition of the NTPase activity. Our results suggest that derivatives of ribavirin-TP with enhanced stability towards hydrolytic attack may be effective inhibitors of the enzyme.

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1 Acta Biochimica Polonica

1 2001

1 Borowski P.

1 Choe J.

1 Haag A.

1 Kulikowski T.

1 Lang M.

1 Niebuhr A.

1 Schmitz H.

1 Siwecka M. A.

1 Wiesch J. S. z.

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Inhibition of the helicase activity of HCV NTPase/helicase by 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide-5'-triphosphate (ribavirin-TP).