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Nucleoside phosphate analogues of biological interest, and their synthesis via aryl nucleoside H-phosphonates as intermediates.

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Cieślak J., Sobkowski M., Jankowska J., Wenska M., Szymczak M., Imiołczyk B., Zagórowska I., Shugar D., Stawiński J., Kraszewski A.

2001

vol. 48

issue 2

429-442

This review presents a brief account of the chemistry and mechanistic aspects of aryl H-phosphonates, and selected applications of this class of compounds as intermediates in the synthesis of a wide range of biologically important analogues of nucleoside phosphates, and oligonucleotides, in which the phosphate moieties are replaced by other structurally related groups. The aryl nucleoside H-phosphonates, compounds of controlled reactivity, have proven to be more versatile and superior to various mixed anhydrides as synthetic intermediates, particularly for preparation of nucleotide analogues bearing P-N or P-S bonds in various configurational arrangements at the phosphate moiety.

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1 Acta Biochimica Polonica

1 2001

1 Cieślak J.

1 Imiołczyk B.

1 Jankowska J.

1 Kraszewski A.

1 Shugar D.

1 Sobkowski M.

1 Stawiński J.

1 Szymczak M.

1 Wenska M.

1 Zagórowska I.

Search results

Nucleoside phosphate analogues of biological interest, and their synthesis via aryl nucleoside H-phosphonates as intermediates.