Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl
Preferences help
Polish version English version Language
enabled [disable] Abstract
Number of results

Results found: 3

Number of results on page
first rewind previous Page / 1 next fast forward last

Search results

Search:
in the keywords:  Gene expression
help Sort By:

help Limit search:
first rewind previous Page / 1 next fast forward last
1
Content available remote

Synergy of feedback mechanisms in gene regulation systems with promoter and repressor transcription factors

100%
Šrobár F.
|
EN
Presence of feedback mechanisms, both positive and negative, in the gene regulation systems is generally appreciated. The present study proposes a diagrammatic representation of these phenomena that affords their exact formulation and reveals some new facts. Topology of feedback relationships is defined by diagram configuration and quantitative evaluation is afforded by analytical apparatus coming with the diagrams. In particular, criterion for occurrence of bistability and synergy of positive and negative feedback are described in exact manner using the concept of transmission functions associated with diagram edges. The approach is demonstrated on genetic regulatory system comprising two genes whose transcription is controlled by activator and repressor proteins mutually competing for binding to the same responsive element of the DNA.
2
Content available remote

Regulation of gene expression in articular cells is influenced by biomechanical loading

88%
Rath B., Springorum H.-R., Deschner J., Lüring C., Tingart M., Grifka J., Schaumburger J., Grässel S.
Open Medicine
|
2012
|
vol. 7
|
issue 4
545-552
3
Content available remote

Investigating gene expression profile of non-small cell lung cancer

88%
Vooder T., Metspalu A.
|
EN
Lung cancer is mainly a lifestyle-associated disease with poor prognosis and the lowest five year survival rate of all types of cancer. Lung cancers are divided into two main groups: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). Surgical treatment is generally indicated in cases of early stage NSCLC, and those patients treated with radical and aggressive surgery have a somewhat better survival rate. The main problems with lung cancer treatment are due to late diagnosis, rapidly developing drug resistance and side effects of the treatment that are experienced by almost all patients. The next step for distinguishing histologically complicated lung cancers and determining optimal treatment strategies is gene expression analysis. Supported by gene expression data, it is possible to prognosticate the course of the disease.
first rewind previous Page / 1 next fast forward last
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.