This paper reviews possibility of glutathione synthesis by microorganisms and its role in living organisms. Glutathione as a tripeptyde containing the -SH and gamma-glutamyl bonds appears to be not only an alternative source of cysteine but also participates in various vital physiological processes. This ubiquitous compound is presenthly in use as a medicament or antidote. Therefore, seachring for alternative means of this production besides the known conventional chemical method is important from biotechnological and economical viewpoint. Also, biomass with elevated content of glutathione could be used as dietary supplement to feeds and foods, cellular enrichment, oxidative and reductive processes and so on in vivo.
It has been commonly accepted that oxidative stress is involved in pathogenesis of many serious and even lethal health disturbances, including neurodegenerative diseases, diabetes, alcoholic disease, viral and bacterial infections. In this paper we discuss the protective antioxidative role of glutathione, the predominant non-protein thiol in mammalian cells. We also emphasize the perspectives of glutathione therapy i.e. application of both cysteine and glutathione precursors.
The activity of rhodanese, 3-mercaptopyruvate sulfurtransferase and g-cystathionase and the content of glutathione and sulfane sulfur compounds were determined in Rana temporaria brain in April. The high sulfane sulfur level observed in the spring seems to be associated with protection against cellular oxidative stress after the period of hibernation with its minimal oxidative metabolism. Key words: sulfane sulfur, sulfurtransferases, glutathione, frog brain
This review summarises the mechanisms of heavy metal tolerance in plants. Plants have many endogenous genetic, biochemical, and physiological properties that make them ideal agents for soil and water remediation. Phytoremediation is widely viewed as an ecological alternative to the environmentally destructive physical remediation methods currently in use.
The Oxalis triangularis transformed plants were regenerated from hairy roots induced by A. rhizogenes LBA 9402. In vitro shoot proliferation of the transformed roots-regenerated plants was 65% higher by than that of the non-transformed ones. In vivo the hairy root syndrome was observed for the transformed roots-regenerated plants. Anthocyanin content in the leaves of non-transformed plants was about 40% higher than in the transformed roots-regenerated ones. In the non-transformed plants, GSH (1,5 mM) enhanced anthocyanin production by 30% at the most, while in the transformed roots-regenerated plants the maximal increase in its production was found on the 2nd and 9th days after the treatment, it reached 230-320% and 750-600% of control, respectively.
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.