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1

Aplication of phytoferritin into food fortification in iron

100%
Zielinska-Dawidziak M.
Biotechnologia
|
2009
|
issue 4
35-39
EN
Various actions have been taken in object to improve human diet in iron with high bioavailibility. One of the new possibility of food fortification is introduction phytoferritin into. In order to do this various strategies are used as increasing of native ferritin supply in human diets as far as application genetic engineering for receiving cultivated plants with high expression of this plant. The most important feature of ferritin introducing into food is its high bioavailability.
2

Conservation of ferritin amino acid sequences

100%
Smol J.
Biotechnologia
|
1997
|
issue 4
135-139
EN
The present review describes the conservation of ferritin amino acid sequences. We investigated the N-terminal amino acid sequence of lupin ferritin. We found that both subunits had the same N-terminal sequence. Our data confirm that subunits are not programmed by different mRNAs but they are a result of posttranslational modification. The smaller subunit has a lower molecular weight probably because of deletion of some amino acids from the C-terminal end. Then we compared the lupin ferritin sequence with other known ferritin sequences from plants and animals. Sequence data showed that the identity of plant sequences was 60-92,5%. This high sequence similarity was improved by analysis of genomic DNA from maize and soybean. Both DNAs share 72,2% nucleotide sequence identity. An additional plant specific sequence (named the transit sequence) was observed at the N-terminal end. This sequence consists of 50 nucleotides. We found the lupin ferritin did not have that sequence. We suggest that the deletion of the transit sequence in lupin ferritin seems to be the result of isolation and purification.
3

Mutant HFE genotype leads to significant iron overload in patients with liver diseases from western Romania

88%
Neghina A.-M., Anghel A., Sporea I., Popescu A., Neghina R., Collins A., Thorstensen K.
Journal of Applied Genetics
|
2009
|
vol. 50
|
issue 2
173-176
EN
The present study aimed at assessing the frequency of HFE mutations (C282Y, H63D and S65C) in western Romanian patients with liver disease of diverse aetiologies suspected of iron overload. A total of 21 patients, all Romanian residents hospitalized with clinical suspicion of iron overload and liver disease, were assayed for C282Y, H63D and S65C mutations, serum ferritin and viral hepatitis markers. Overall, 9 out of the 21 patients (42.86%) were found to harbour mutations in the HFE gene: 4 homozygotes C282Y (19.0%), 1 compound heterozygote C282Y/H63D (4.8%), 1 single heterozygote C282Y (4.8%), 2 single heterozygotes H63D (9.5%), 1 single heterozygote S65C (4.8%), and 12 wild-type cases (57.1%). Among the subgroup of 10 patients with the most prominent signs of iron overload (hyperferritinaemia and/or hepatocyte iron score 1), without hepatocellular carcinoma, the HFE genotypes were conclusive in 5 cases (50%). They had significantly increased ferritin levels compared to wild-type cases (P = 0.029). The inclusion of iron studies during routine clinical visits, coupled with the availability of HFE genotyping for family and population studies, should facilitate the early detection of hereditary haemochromatosis in Romania.
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