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1

Pathogenesis of polyglobulin in patients after kidney transplantation

100%
Darocha Z., Kokot F., Bar A., Lenc P.
Postępy Higieny i Medycyny Doświadczalnej
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1995
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vol. 49
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issue 2
181-187
2

Effects of phenylhydrazine or recombinant human erythropoietin on deformability and activity of dehydrogenase glucose-6-phosphate and acetylcholinesterase in Wistar rats blood enriched in reticulocytes

100%
Nowak E., Wyrwicz G., Dabrowski Z., Smolenski O., Spodaryk K.
Folia Biologica
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2003
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vol. 51
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issue 3-4
195-199
EN
Deformability and activity of the enzymes: acetylcholinesterase (AChE) and dehydrogenase glucose-6-phosphate (G-6-PD), were assayed for RBC enriched in immature reticulocytes. Reticulocytosis was evoked by administration of two different drugs: recombinant human erythropoietin (rHuEPO) and phenylhydrazine (PHZ) to two groups of Wistar rats. After treatment with the former compound, a group of animals exhibited 17,33 % reticulocytes in blood whereas a group of rats treated with the latter drug reached 57,66 % of these cells in blood. A marked decrease in RBC deformability was found in both groups of animals. AChE did not significantly change activity neither in PHZ-treated nor in rHuEPO-treated rats, whereas G-6-PD activity was significantly decreased in the PHZ-treated group.
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