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Interactions between endogenous opioid peptides and sex steroids in the central nervous system

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Bidzinska B., Jedrzejczuk D.
Postępy Higieny i Medycyny Doświadczalnej
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1995
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vol. 49
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issue 4
523-530
EN
Gonadal steroids and beta-endorphin (beta-EP) (and probably other - EOP endogenous opioid peptides) play a role of the pivotal hormones involved in integration of several neurophysiological mechanisms.The reproductive system could be disturbed at hypothalmic level by interference of beta-EP witn GnRH secretion and/or at pituitary level with response of gonadotropes to GnRH.Gonadal steriods, through a feedback mechanism, may exert similar effect on hypothalmus and/or pituitary.The action of EOP on the hypothalmo-pituitary-gonadal axis may be influenced by physiological and pathological changes in gonadal steroids during puberty, menstrual cycle in females, menopause, in case of idiopathic delayed puberty, in patients with gonadal dysgenesis or after castration.EOP seems to be "gonadaostat" system that have a key role in the transmission of gonadal feedback signals to the brain.
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