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Controlled release of amoxicillin from bacterial cellulose membranes

100%
Pavaloiu R.-D., Stoica A., Stroescu M., Dobre T.
Open Chemistry
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2014
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vol. 12
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issue 9
962-967
EN
Bacterial cellulose (BC), a natural polymer with unique physical and mechanical properties, has several applications in the biomedical field, including drug loading and controlled drug delivery. For this study, a Box-Behnken experimental design was employed as a statistical tool to optimize the release of a model drug, amoxicillin, from BC membranes. Independent variables studied were the concentration of the drug (X1), the concentration of glycerol (X2) and the concentration of a permeation enhancer (X3). From the variables studied, drug concentration had the highest effect on drug release. Among the other independent variables, th linear and quadratic X2 terms, the linear X3 term and the interaction term X2X3 were found to affect the release of amoxicillin from bacterial cellulose membranes.
2
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Development of cephalexin-loaded poly(ethyl cyanoacrylate) colloidal nanospheres

88%
Yordanov G.
Open Chemistry
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2012
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vol. 10
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issue 2
305-312
EN
This article considers the preparation and physicochemical characterization of a novel colloidal formulation of the β-lactam antibiotic cephalexin, loaded in poly(ethyl cyanoacrylate) colloidal nanospheres. The drug was loaded by means of drug incorporation in the interior of poly(ethyl cyanoacrylate) particles during the polymerization of the respective monomer in aqueous medium. The obtained colloids were characterized by scanning electron microscopy, dynamic and electrophoretic light scattering, Fourier transform infrared and nuclear magnetic resonance spectroscopy. It was found that the drug loading efficiency depends on the initial concentration of monomer and cephalexin in the polymerization medium. The average size of cephalexin-loaded particles was around 400 nm and did not depend significantly on the concentrations of drug and monomer. Drug-loaded particles with drug content as high as 21% (w/w) were prepared. The drug release kinetics was studied in physiological phosphate-buffered saline. It was found that a biexponential model could describe well the experimental release kinetics. [...]
3
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Erratum to: “Synthesis and characterization of molecularly imprinted polymer for controlled release of tramadol”

75%
Azodi-Deilami S., Abdouss M., Rezvaneh Seyedi S.
Open Chemistry
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2011
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vol. 9
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issue 3
499-499
EN
The original version of the article was published in Cent. Eur. J. Chem., Vol. 8(3), (2010), pp. 687–695. Unfortunately, the original version of this article contains mistakes in the Authors names section. There should be: Saman Azodi-Deilami1, Majid Abdouss1 and S. Rezvaneh Seyedi2.
4
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Synthesis and characterization of molecularly imprinted polymer for controlled release of tramadol

75%
Azodi-Deilamia S., Abdoussa M., Rezvaneh Seyedib S.
Open Chemistry
|
2010
|
vol. 8
|
issue 3
687-695
EN
In this paper, we describe how to prepare a highly selective imprinted polymer by a bulk polymerization technique. We used tramadol as the template, (MAA) as functional monomers, and (EGDMA) as the cross-linker in chloroform as solvent. Results from Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), Scanning Electron microscopy (SEM) show that this imprinted sorbent exhibits good recognition and high affinity for tramadol. Selectivity of molecularly imprinted polympers (MIP) was evaluated by comparing several substances with similar molecular structures to that of tramadol. Controlled release of tramadol from MIPs was investigated through in vitro dissolution tests and by measuring the absorbance at λmax of 272 nm by (HPLC-UV). The dissolution media employed were hydrochloric acid pH 3.0 and phosphate buffers, pH 5.0 and 7.4, maintained at 37 and 25 ± 0.5°C. The results show the ability of MIP polymers to control tramadol release. In all cases, the release of MIPs was deferred for a longer time as compared to NMIP. At a pH of 7.4 and 25°C slower release of tramadol imprinted polymer occurred. [...]
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