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Comparison of IFCC and NGSP methods for determination of glycated haemoglobin using advanced regression techniques

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Mrázová V., Mocák J., Bednárová A., Balla J.
Open Chemistry
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2010
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vol. 8
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issue 6
1216-1222
EN
The objective of this work was a correct statistical comparison of two assay methods for determination of glycated haemoglobin HbA1c. The immunoturbidimetric determination of HbA1c was performed in two ways: using an automatic analyser Hitachi 912, calibrated according to the IFCC reference system (International Federation of Clinical Chemistry and Laboratory Medicine) and using an analyser Advia 1200 and the NGSP reference system (National Glycohaemoglobin Standardization Program). For statistical comparison of these two analytical methods several advanced regression methods were used, which respect random errors of both compared methods. Specifically, Deming regression with and without weights, orthogonal regression, and Passing-Bablok regression were employed. The results demonstrate that the investigated analytical assay methods do not correspond to each other. The summarized results indicate usefulness of better harmonisation of two existing reference systems.
2
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Effectiveness of electrical stimulation and low-intensity laser therapy on diabetic neuropathy: A systematic review

100%
Adehunoluwa E. A., Adesina M. A., Adeulure T. G., Akinfolarin Y. T., Babatunde K. O., Efunniyi A. O., Mamud O. S., Oyejola O. G., Tiamiyu O. M., Olajire T. I.
World News of Natural Sciences
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2019
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vol. 23
110-127
EN
Diabetes mellitus (DM) is a group of metabolic diseases which typically presents with frequent urination, increased thirst and increased hunger. DM be classified into three main types: type I (insulin-dependent DM), type-II (non-insulin dependent DM) and type III (gestational DM). Diabetes is a group of diseases of global health significance as 382 million people worldwide had diabetes in the year 2013 and this was projected to increase to an estimated 415 million in 2015. Damage to the nerves of the body (diabetic neuropathy) is the most common complication of diabetes. The signs and symptoms of diabetic neuropathy include numbness, diminished sensation, pain etc. Various types of electrotherapy, such as transcutaneous electrical nerve stimulation (TENS), pulsed-dose electrical stimulation, frequency-modulated electromagnetic neural stimulation, have been reported effective in managing diabetic neuropathy. This study is a systematic review of the evidence to enable the determination of the effectiveness of electrical stimulation and low-intensity laser therapy (LILT), and also aid their recommendation if proven to be effective. The outcome of this study was that TENS and other forms of electrical stimulation reviewed in this study may be effective and safe non-pharmacological treatment modalities in relieving the symptoms associated with diabetic neuropathy. The effectiveness of LILT couldn’t be determined due to the different parameters used to evaluate patients’ outcome and limited number of studies. Authors recommend that further randomized controlled trials with similar methodological parameters and studies with higher quality of evidences are needed to establish the true effectiveness of these modalities in diabetic neuropathy.
3
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Coronary flow velocity reserve predicts survival in non-diabetic patients

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Nemes A., Balázs E., Pintér K., Egyed Á., Csanády M., Forster T.
Open Medicine
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2012
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vol. 7
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issue 6
817-822
4
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In Vitro Evaluation of Alpha-Glucosidase and Alpha-Amylase Inhibitory Activity of Copper(II) Complex of King of Bitters Crude Extract

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Oladipo M. A., Ojo A. O., Ishola K. T., Adepoju A. J.
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EN
Diabetes mellitus is a chronic disorder which characterized by high concentration of blood glucose. It is known as one of the major deadly diseases that require a serious attention. Many conventional drugs which have been employing in treating the disease are reported to less effective, expensive and some are not locally available. Therefore, in order to search for more effective, inexpensive and locally available drug, this study investigated antidiabetic activity of Cu(II) complex of King of bitters leaves crude extract. The crude extract of the plant was obtained in n-hexane. The metal complex of the crude extract was synthesized and characterized using solubility tests, Infrared and Ultraviolet-Visible spectroscopic analyses. The antidiabetic activities of the crude extract and its metal complex were examined against α-amylase and α-glucosidase enzymes while acarbose drug was employed as a standard drug. The metal complex showed different degrees of solubility in different solvents. Infrared analysis suggested coordination of the crude extract to the metal ion through oxygen donor atom while the formation of the complex was affirmed through the occurrence of d-d transitions in the visible region of the metal complex. The crude extract and its metal complex displayed good activities against α-amylase and α-glucosidase enzymes. It is suggested that the compounds are promising candidates to inhibit α-amylase and α-glucosidase.
5
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Microvascular angina in diabetic patients with uninjured coronary arteries

88%
Sucato V., Evola S., Triolo O., Trovato R., Pace G., Quagliana A., Magro S., Tona G., Novo G., Novo S.
Open Medicine
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2012
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vol. 7
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issue 6
823-828
6
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Risk factors in a patient with fungemia caused by fluconazole-resistant Candida albicans

75%
Kaya A., Yucel M., Yucel I.
Open Medicine
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2008
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vol. 3
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issue 3
358-360
EN
Blood stream infections due to Candida species are becoming increasingly important causes of morbidity and mortality in hospitalized patients. Risk factors that predispose patients to developing invasive Candida infections have been documented as, iatrogenic and/or nosocomial conditions and immunosuppression. In the present report, we want to emphasize the risk factors that predispose individuals to the development of candidemia, particularly those that are relevant to our patient. We describe a female patient with diabetes mellitus who had been receiving glucocorticoids for 20 years as replacement therapy for hypopituitarism resulting from hypophysis adenoma surgery. The patient received antibiotic therapy for recurrent wound infections and was hospitalized for a long time, including a period in the intensive care unit and instrumented. The patient eventually succumbed to fungemia caused by a fluconazole-resistant strain of C. albicans strain.
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