Search results

Search:
in the keywords: DYSTROPHY

Sort By:

Limit search:

Human cord blood cells can differentiate into retinal nerve cells

100%

Koike-Kiriyama N., Adachi Y., Minamino K., Iwasaki M., Nakano K., Koike Y., Yamada H., Mukaide H., Shigematsu A., Mizokami T., Matsumura M., Ikehara S.

Acta Neurobiologiae Experimentalis

2007

vol. 67

issue 4

359-365

Retinal degeneration and dystrophy are the major causes of blindness in the developed world. It has been reported that human cord blood cells (HCBCs) can differentiate into neuron-like cells in vitro. We have recently demonstrated that bone marrow cells (BMCs) of both mice and rats can differentiate into retinal nerve cells (RNCs). In the present study, we show the differentiation capacity of HCBCs into RNCs in vivo. We transplanted lineage-negative HCBCs into the subretinal space of severe combined immunodeficiency (SCID) mice. Two weeks after the transplantation, some of the transplanted cells expressed human nestin, human MAP2, human neuron specific enolase (NSE), beta-III tubulin and also rhodopsin. These results indicate that HCBCs can differentiate into RNCs and suggest that our new strategy could be used for the regeneration of retinal nerve cells in degenerative or dystrophic diseases.

Refine search results

1 Acta Neurobiologiae Experimentalis

1 2007

1 Adachi Y.

1 Ikehara S.

1 Iwasaki M.

1 Koike Y.

1 Koike-Kiriyama N.

1 Matsumura M.

1 Minamino K.

1 Mizokami T.

1 Mukaide H.

1 Nakano K.

1 Shigematsu A.

1 Yamada H.

Search results

Human cord blood cells can differentiate into retinal nerve cells