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Nociceptive dorsal root ganglion neurons

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Szulczyk P., Rola R., Szulczyk B., Witkowski G.
Postępy Higieny i Medycyny Doświadczalnej
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2002
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vol. 56
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issue 3
361-375
EN
Pain is generated by activation of specific dorsal root ganglion (DRG) neurons termed the nociceptive neurons. The nociceptive DRG neurons express 3 categories of ionic channels a. Channels gated by pain stimuli, b. Channels responsible for the transmission of information from sensory receptors to the spinal cord, c. Channels resposible for the release of neurotransmitters in the spinal cord. There is evidency that kinetic properties, molecular structure and functional significance of the ionic channels expressed in nociceptive DRG neurons are different compared to the other types of DRG neurons. The ionic channels are strictly controlled by receptors for neurotransmitters expressed in the plasma membrane of nociceptive DRG neurons.
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Lidocaine inhibits neurite growth in mouse dorsal root ganglion cells in culture

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Hiruma H., Maruyama H., Simada Z. B., Katakura T., Hoka S., Takenaka T., Kawakami T.
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EN
Recent clinical and experimental studies suggest the effectiveness of lidocaine in blocking neuropathic pain. Because it has been demonstrated that the pathogenetic mechanisms of neuropathic pain involve morphological changes in afferent neuronal terminals onto spinal cord, we examined the effects of lidocaine on neurite growth in isolated mouse dorsal root ganglion cells in culture. Incubation for 2-42 h with various concentrations of lidocaine (0.006 mM, 0.6 mM, and 30 mM) reduced the number of cells exhibiting neurites. The effects were time- and dose-dependent. Lidocaine therefore may exert its pharmacological effect, at least in part, by changing neuronal structures derived from sensory neurons.
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