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Evidence for a D4 dopamine receptor decreasing serotonin N-acetyltransferese activity in chick retina

100%
Zawilska J. B., Nowak J. Z.
Acta Neurobiologiae Experimentalis
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1993
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vol. 53
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issue 3
473-474
EN
In verebrate retina melatonim (MEL) level and activity of serotonim N-acetyltransferase (NAT; a key regulatory enzyme in MEL biosynthetic pathway) fluctuate with a light-dependent circadian rhythm, with peak values at night. The nocturnal increase of MEL synthesis is dramatically suppressed by acute exposure of animals to light. Experimental evidence suggest that the inhibitory effect of light on the MEL-generating system in retina is mediated. at least partially, by dopamine (DA) acting on D2-like DA receptors (2,3). In this work we verified a subtype of DA receptors regulating NAT activity in the retina of chick.
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Dopamine, learning, and reward-seeking behavior

80%
Arias-Carrion O., Poeppel E.
Acta Neurobiologiae Experimentalis
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2007
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vol. 67
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issue 4
481-488
EN
Dopaminergic neurons of the midbrain are the main source of dopamine (DA) in the brain. DA has been shown to be involved in the control of movements, the signaling of error in prediction of reward, motivation, and cognition. Cerebral DA depletion is the hallmark of Parkinson's disease (PD). Other pathological states have also been associated with DA dysfunction, such as schizophrenia, autism, and attention deficit hyperactivity disorder in children, as well as drug abuse. DA is closely associated with reward-seeking behaviors, such as approach, consumption, and addiction. Recent researches suggest that the firing of DA neurons is a motivational substance as a consequence of reward-anticipation. This hypothesis is based on the evidence that, when a reward is greater than expected, the firing of certain DA neurons increases, which consequently increases desire or motivation towards the reward.
3

Dopamine receptors: structure, characterization and functions

80%
Zawilska J. B.
Postępy Higieny i Medycyny Doświadczalnej
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2003
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vol. 57
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issue 3
293-322
EN
Dopamine (DA) is an important neurotransmitter/neuromodulator that plays various functions within the body. In the central nervous system, DA is involved in the control of locomotion, cognition, emotion, neuroendocrine secretion and function of retinal cells. In the periphery, DA participates in the regulation of homeostasis, vascular tone and hormone secretion. The diverse physiological functions of DA are mediated by at least five distinct membrane bound receptors, i.e. D1 and D5 -members of D1 family, and D2, D3, D4 ? members of D2 family of DA receptors. All DA receptors belong to the superfamily of G-protein-coupled receptors. This survey summarizes current knowledge on the molecular and pharmacological characterization of DA receptors, their role in the regulation of various processes in an organism, and involvement in the therapy of several disorders, in particular in the treatment of Parkinson?s disease, schizophrenia, and hypertension.
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