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1

- a new way of research on mechanisms

100%
Wolowiec D., Ffrench M.
Postępy Higieny i Medycyny Doświadczalnej
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1993
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vol. 47
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issue 3
183-191
EN
constitute a regulatory subunit of the complex. On the ground of their primary structure they are divided into two classes A and B, both necessary for the . activates histone H1 kinase and becomes destroyed by earlier than and plays an important role in the . A and B may be involvent in the development of either directly inappropriate expression of the cyclin A gene caused by hepatitis B virus in hepatocellular carcinoma, or interactions of this cyclin with factors paricipating in the regulation of cell proliferation or indirectly by phosphorylation of some oncogene or antioncogene proteins by a cdk (cyclin dependent kinase).
2

Relation betwwn DNA replication and DNA repair in human lymphocytes proliferating in vitro in the presence and in absence of mutagen

100%
Szyfter K., Wiktorowicz K., Wielgosz M. S., Zajaczek S., Kujawski M., Jaloszynski P., Czub M., Markowska M.
Journal of Applied Genetics
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1995
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vol. 36
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issue 4
379-388
EN
The effects of mutagens on DNA replication and DNA repair were studied in peripheral blood lymphocytes (BPL) obtained 21 healthy subjects, 2 samples from healthy heterozygote of Xeroderma pigmentosum (XP) and 2 samples from patient with clinically recognized XP.Inter-individual variations were found in DNA replication and in the level of spontanous DNA repair measured under standard culture condition.Exposure of human PBL proliferating in vitro to B(a)P was followed by a partial inhibition of replicative DNA synthesis in all subjects and by induction of DNA repair in healthy subjects.In XP patients DNA repair sythesis remained at the level attributed to spontaneous DNA repair.The response to mutagen varied individually.Results were analysed statistically.It was established that the studied indices of DNA synthesis correlete well with each other.The highest correlation was found between the levels of spontaneous and B(a)P-induced DNA repair.It is concluded that the level of spontaneous DNA repair is predictive for an estimation of cells ability to repair DNA damage.Inter-individual variations in the inhibition of DNA replication and in DNA repair sythesis are also dependet on the type of mutagen as shown by effect of other mutagens.Different effects of mutagen exposure on the inhibition of DNA replicative sythesis and induction of DNA repair can be explained by genetically controlled differences in the activity of enzymes responsible for mutagen processing and lesion removal.
3

The role of cell cycle co-ordination in the development of nuclear transfer reconstructed embryos

100%
Campbell K. H. S., Ritchie W., Loi P., McWhir J., Wilmut i.
Biotechnologia
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1996
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issue 2
68-80
EN
The purpose of this paper is to review information regardind the co-ordination of nuclear and cytoplasmic events during embryo reconstruction, in particular the direct and indirect effects of maturation (meiosis) mitosis promoting factor (MPF), upon the transferred nucleus.These will be discussed in relation to DNA replication, the maintenance of correct ploidy, the occurence is primarilu concerned with the reconstruction of mammalian embryos, specific examples from amphibians will also be cited.
4

Is tRNA only a translation factor or also a regulator of other processes?

88%
Wegrzyn G., Wegrzyn A.
Journal of Applied Genetics
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2008
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vol. 49
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issue 1
115-122
EN
Abstract. tRNA has been discovered as a factor playing a central role in the translation of genetic information (encoded in DNA and transcribed to mRNA) into amino acid sequences of proteins. However, subsequent studies led to the hypothesis that during evolution, tRNA originated in replication, not translation. Indeed, there are many examples of tRNA-like molecules playing roles in reactions other than translation, including replication of various replicons. In this review, we have focused on functions of tRNA molecules (not tRNA-like structures) outside of their direct roles in translation as factors for a passive transportation of amino acids into a ribosome and deciphering triplets of nucleotides in codons of mRNA. Interestingly, it appears that such tRNA-dependent reactions are effective only when tRNA is uncharged. The most spectacular examples come from bacterial cells and include induction of the stringent control, regulation of transcription of some operons, and control of replication of ColE1-type plasmids. Recent studies indicated that tRNA (not only pre-tRNA, shown previously to be capable of self-excision of intron sequences) can be responsible for specific cleavage of another transcript, a ColE1 plasmid-encoded RNA I, which is involved in the regulation of plasmid DNA replication initiation. If this reaction is not restricted to RNA I but represents a more general phenomenon, one might suspect a potential role for uncharged tRNA molecules in regulation of various processes, whose efficiency depends on tRNA-cleavable RNAs. This kind of regulation would provide a possibility for a cell to respond to different nutrition conditions resulting in different levels of tRNA aminoacylation.
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