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1

DNA adducts - characterization and the role in chemical carcinogenesis

100%
Baer-Dubowska W.
|
|
vol. 46
|
issue 3
295-308
EN
A review of the metabolic pathways and interaction with DNA of benzo(a)pyrene and some other carcinogens is presented. Consideration is given to the formation and persistens of adducts in relation to carcinogenic process.
2

Analysis of aromatic DNA adducts in the inhabitants of upper Silesia

100%
Grzybowska E.
Postępy Higieny i Medycyny Doświadczalnej
|
1997
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vol. 51
|
issue 2
185-203
EN
Aromatic DNA adducts levels were measured in white blood cells collected from three groups of volunteers: occupationally exposed group (cokery workers), environmentally exposed group (residents from Silesia), control group (inhabitants of Biala Podlaska) using ELISA and 32P-postlabelling methods. The highest level of DNA adducts was observed in the occupationally exposed group, slightly lower in the environmentally exposed group and much lower in the control group. Seasonal variations in the adducts levels were found in total white blood cells and in lymphocytes showing that the levels of DNA adducts reflect the present exposure to genotoxic agents in the air. It was also shown using 32P-postlabelling with HPLC that not only adducts with polycyclic aromatic hydrocarbons were found in human DNA.
3

Molecular and cellular basis of interactions

80%
Zastawny T. H., Olinski R.
Postępy Higieny i Medycyny Doświadczalnej
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1993
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vol. 47
|
issue 2
101-121
EN
Cis-DDP is an with activity against various . It is generally accepted that is the of cis-DDP. The present paper describes the binding models of cis-DDP to DNA, structural distortion in DNA induced by covalent binding of cis-DDP and repair studies of Pt-DNA adducts in pro- and eucariotic systems. We also discuss the possible mechanisms of acquired of to cis-DDP and analoques, and potential clinical implication of this fenomenon.
4

Analysis od DNA adducts in molecular epidemiology of human cancer

80%
Szyfter K., Baer-Dubowska W., Brauze D.
Postępy Higieny i Medycyny Doświadczalnej
|
1993
|
vol. 47
|
issue 4
231-248
EN
The techniques applicable for identification and quantitation are critically reviewed. The review also present the data concerning an analysis of DNA adducts resulted from occupational exposure, tobacco smoking, diet and chemotherapy of tumors.
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