Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl
Preferences help
Polish version English version Language
enabled [disable] Abstract
Number of results

Results found: 1

Number of results on page
first rewind previous Page / 1 next fast forward last

Search results

Search:
in the keywords:  DIFLUOROMETHYLORNITHINE
help Sort By:

help Limit search:
first rewind previous Page / 1 next fast forward last
1
Content available remote

Difluoromethylornithine counteracts lesion-induced astrogliosis in rat hippocampus: enhancement of inhibitory effect by combined treatment with GM1 ganglioside

100%
Jaglinski W., Skup M., Zaremba M., Oderfeld-Nowak B.
Acta Neurobiologiae Experimentalis
|
1996
|
vol. 56
|
issue 2
549-553
EN
The effect of difluoromethylornithine (DFMO), an irrevesible inhibitor of ornithine decarboxylase (ODC), the rate limiting enzyme of polyamine biosynthesis, and its combined action with GM1 ganglioside, was studied on the GFAP content in a model of remote astrogliosis evoked in the hippocampus by latral fimbria transection.DFMO markedly suppressed hipocampal gliosis as measured by GFAP immunoblotting seven days postsurgery.Combined treatment with DFMO and GM1 ganglioside produced a stronger suppressive effect than DFMO.The results support the hypothesis of a causal link between lesion induced events:polyamine biosynthesis and astroglial reaction.Potentation of the inhibitory effect of DFMO by GM1 ganglioside suggest that the latter does not act through the mechanism involving ODC suppression.
first rewind previous Page / 1 next fast forward last
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.