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Macrophages and HIV-1-associated dementia

100%

Bovem L. A.

vol. 48

issue 4

273-279

One of the strongest predictors for HIV-1-associated dementia is the presence of monocytic infiltration in perivascular areas of the brain. Therefore, macrophages have been suggested to play a major role in the development of this disease. This review focuses on possible mechanisms through which the macrophage may enhance disease progression by mediating neuronal damage.

Molecular genetics of Alzheimer?s disease: Presenilin 1 gene analysis in a cohort of patients from the Pozna? region

100%

Kowalska A., Wender M., Florczak J., Pruchnik-Wolinska D., Modestowicz R., Szczech J., Rossa G., Kozubski W.

Journal of Applied Genetics

2003

vol. 44

issue 2

231-234

Alzheimer?s disease (AD) is a progressive neurodegenerative disorder characterized by memory loss and personality changes. Pathological hallmarks of AD are: deposition of amyloid plaques and neurofibrillary tangles in the brain, accompanied by neuronal and synaptic loss. The genetic background of AD is heterogeneous and strongly depends on the form of the disease. In most of the families with early-onset AD (EOAD) (10% of the total population of patients), the disease segregates as an autosomal dominant fully penetrant trait. To date, some missense mutations in three genes encoding the amyloid precursor protein, presenilin 1 (PS1) and 2 (PS2) have been found to cause familial EOAD. We screened for mutations in the presenilin genes in a sample of 55 patients with familial or sporadic form of EOAD from the Poznan region. We found 4 missense mutations in the PS1 gene: A246E in exon 7, P267L in exon 8, E318G in exon 9, and L424R in exon 12 among 5 unrelated patients. The frequency of PS1 mutations was 11% (5 of 55) in the whole sample of the patients with EOAD or 50% (3 of 6) if the analysis was restricted to familial cases with a positive history of dementia in the patient?s family.

Lipid metabolism parameters in patients with Alzheimer disease and their first degree relatives

88%

Czyzewski K., Lalowski M. M., Pfeffer A., Barcikowska M.

Acta Neurobiologiae Experimentalis

2001

vol. 61

issue 1

21-26

Recently, it was suggested that the presence of total cholesterol (TC), age and sex interaction in Alzheimers type dementia (AD) is linked with the apolipoprotein E (APOE) genotype. Our objective was to determine whether the serum lipid profile in AD patients and their first degree non-demented relatives of a certain age (NDR) was dependent on APOE genotype. We included 28 mild to moderate AD and 30 NDR according to DSM-III-R and NINCDS-ADRDA criteria. NDR individuals were investigated in an age group similar to the AD group (brother-sister relationship) and in a group including younger individuals (AD patients-children relationship). Our data indicate significant differences between decreased total cholesterol and low density lipoprotein cholesterol ratio in the group of AD patients versus NDR individuals of similar age, independent of APOE genotype, and an increased total cholesterol and low density lipoprotein cholesterol ratio in a group of AD patients versus their children of the same genotype. There was no significant correlation between triglycerides and high density lipoprotein levels with APOE genotype in any of the tested groups. In conclusion, there was a decreased selected lipid serum profile parameters in AD compared to age matched non demented first degree relatives.

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1 Acta Neurobiologiae Experimentalis

1 Archivum Immunologiae et Therapiae Experimentalis

1 Journal of Applied Genetics

1 2003

1 2001

1 2000

1 Barcikowska M.

1 Bovem L. A.

1 Czyzewski K.

1 Florczak J.

1 Kowalska A.

1 Kozubski W.

1 Lalowski M. M.

1 Modestowicz R.

1 Pfeffer A.

1 Pruchnik-Wolinska D.

1 Rossa G.

1 Szczech J.

1 Wender M.

Search results

Macrophages and HIV-1-associated dementia

Molecular genetics of Alzheimer?s disease: Presenilin 1 gene analysis in a cohort of patients from the Pozna? region

Lipid metabolism parameters in patients with Alzheimer disease and their first degree relatives