Search results

Search:
in the keywords: Cyclopenta[b]quinoline

Sort By:

Limit search:

A TLC Study of the lipophilicity of thirty-two acetylcholinesterase inhibitors - 1,2,3,4-tetrahydroacridine and 2,3-dihydro-1H-cyclopenta[b]quinoline derivatives

100%

Szymański P., Skibiński R., Liszka M., Jargieło I., Mikiciuk-Olasik E., Komsta Ł.

Open Chemistry

2013

vol. 11

issue 6

927-934

The lipophilicity of thirty-two novel acetylcholinesterase (AChE) inhibitors - 1,2,3,4-tetrahydroacridine and 2,3-dihydro-1H-cyclopenta[b]quinoline derivatives was studied by thin layer chromatography. The analyzed compounds were chromatographed on RP-18, RP-8, RP-2, CN and NH2 stationary phases with dioxane - citric buffer pH 3.0 binary mobile phases containing different proportions of dioxane. RM values for pure water were extrapolated from the linear Soczewiński-Wachtmeister equation and six compounds with known literature log P values were used as reference calibration data set for computation of experimental log P values. [...] The obtained results were compared with computationally calculated partition coefficients values (AlogPs, AClogP, AlogP, MlogP, KOWWIN, XlogP2, XlogP3) by PCA and significant differences between them were observed.

Refine search results

1 Open Chemistry

1 2013

1 Jargieło I.

1 Komsta Ł.

1 Liszka M.

1 Mikiciuk-Olasik E.

1 Skibiński R.

1 Szymański P.

Search results

A TLC Study of the lipophilicity of thirty-two acetylcholinesterase inhibitors - 1,2,3,4-tetrahydroacridine and 2,3-dihydro-1H-cyclopenta[b]quinoline derivatives