Search results

1

Immunometabolic role of leptin and adiponectin in atherosclerosis: relationships with cardiovascular complications in rheumatic diseases

100%

Feijóo-Bandín S., Rodríguez-Penas D., García-Rúa V., Mosquera-Leal A., Roselló-Lletí E., Portolés M., Rivera M., González-Juanatey J. R., Lago F.

|

vol. 1

18-27

EN

Patients with rheumatic diseases have an increased risk of mortality by cardiovascular events. In fact, several rheumatic diseases such as rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus and ankylosing spondylitis are associated with a higher prevalence of cardiovascular diseases (CVDs). Although, traditional cardiovascular risk factors have been involved in the pathogenesis of cardiovascular diseases in rheumatic patients, these alterations do not explain completely the enhanced cardiovascular risk in this population. Obesity and its pathologic alteration of fat mass and dysfunction, due to an altered pattern of secretion of pro-inflammatory adipokines, could be one of the links between cardiovascular and rheumatic diseases. Indeed, the incidence of CVDs is augmented in obese individuals with rheumatic disorders. Thus, in this review we explore in detail the relationships among leptin and adiponectin with rheumatic diseases and cardiovascular complications by giving to the reader a holistic vision and several suggestions for future perspectives and potential clinical implications.

2

Microarray technology in the study of genetic determinants of cardiovascular diseases

100%

Gluba A., Rysz J., Pietrucha T.

Open Medicine

|

2009

|

vol. 4

|

issue 1

1-10

EN

Microarray, a miniaturized glass slide or membrane with immobilized DNA probes, is a powerful tool for the analysis of mutations, gene expression and sequencing. This technique requires chip (glass slide or membrane) fabrication, preparation of probes and labelled targets, hybridization and data analysis. Microarrays give the possibility to evaluate a wide spectrum of candidate genes, to simultaneously observe interaction of genes, to detect polymorphisms within genes and identify therapeutic targets. Coronary artery disease being a major cause of death, is a disorder influenced by either genetic or environmental factors. Microarray analysis of gene expression can be used to identify genes involved in disease progression and in disease reduction. Chips also allow for the throughput and simultaneous analysis of a great variety of cell types such as cardiomyocytes, monocytes, macrophages, smooth muscle, endothelial, and fibroblasts and chemical mediators involved in cardiovascular disease pathology, their interactions and cumulative effects.

3

Addressing Cardiovascular Disease Risk in HungarianAmerican Populations: A Cultural Exploration of Transdisciplinary Health Promotion

100%

Laszlo N., Aboul-Enein B. H., Bernstein J., Kruk J.

Central European Journal of Sport Sciences and Medicine

|

2017

|

vol. 19

|

issue 3

31-41

EN

Hungarian Americans share a unique culture of food traditions associated with their value system and way of life. Researchers, health care providers, and nutrition professionals counseling and treating a Hungarian-American population should develop a baseline of cultural understanding to achieve successful and long-lasting behavior change outcomes. The leading causes of death among Hungarians include ischemic heart disease (21.3%), stroke (13.4%), and cirrhosis (5.8%); all are directly or indirectly attributed to a traditional Hungarian diet coupled with a sedentary lifestyle. Health behaviors among Hungarian Americans can be partially explained by the Health Belief Model’s value-expectancy construct. Understanding cultural expectations and their associated values serve as a foundation for health promotion programming to reduce risk of cardiovascular disease and comorbidities. This review explored numerous facets of Hungarian-American dietary habits in psychosocial, economic, historical, and cultural contexts. Health education and health promotion considerations were also examined.

4

Intervention for cardiovascular risk factors decreases adipocyte fatty acid-binding protein levels in males - a pilot study

100%

Sovova E., Kaletova M., Stejskal D., Kaminek M., Budikova M., Metelkova I., Horakova D., Sova M., Sovova M., Palcik J., Zapletalova J.

|

EN

Cardiovascular disease (CVD) remains the leading cause of mortality in developed countries. According to the 2012 European Guidelines on Cardiovascular Disease Prevention in Clinical Practice, family history is a cornerstone for risk stratification of CVD. First-degree relatives are persons in whom CVD should be assessed and targeted intervention should be performed. The aims of this pilot study were (i) to determine risk factors (RFs) for cardiovascular disease (CVD) in a group of first-degree relatives of patients with CVD at baseline and after 1 year, (ii) to measure adipocyte fatty acid-binding protein (A-FABP) levels as a potential connecting link between metabolic disease and atherosclerosis, and (iii) to determine the impact of targeted intervention on these parameters. The study comprised 62 asymptomatic subjects (41 males; mean age of 53.8±8.3 years). Preventive examinations and interventions were carried out at baseline and at 1-year follow-up to assess RFs and evaluate A-FABP levels. At 1 year, males had significantly lower levels of cholesterol (median 5.18 vs 4.67, p=0.005), HDL (median 1.24 vs 1.14, p=0.021), LDL (median 3.08 vs 2.46, p=0.021), ApoB (median 0.99 vs 0.82, p=0.012) and A-FABP (median 19.84 vs 16.73, p = 0.015). In females after 1 year, only significantly lower levels of fibrinogen (median 3.10 vs 2.79, p=0.043) were found. All subjects were clinically examined or contacted by phone after a mean of 36.7 months (range, 11–55). Over that time, no serious complications were noted. In males, intervention for RFs leads to lower levels of A-FABP as a potential RF linking metabolic syndrome to atherosclerosis.

5

Evaluation of selected lipid parameters and blood pressure in ethnically-homogenous population of middle-aged persons, depending on gender, age and body mass

88%

Buciński A., Romaszko J., Targoński R., Cichowski L., Romaszko E., Zakrzewski A., Wnuk M.

Open Medicine

|

2010

|

vol. 5

|

issue 4

486-494

EN

The study is a retrospective analysis of data obtained from a cardiovascular disease prevention program financed by the National Health Fund (Poland). The aim of the study was to evaluate the population to demonstrate the prevalence of favourable and unfavourable lipid parameters and blood pressure values depending on age and BMI. A total of 2,616 subjects were included in the study (811 men and 1805 women aged between 35 and 55 years of age) who perceived themselves as completely healthy individuals and in whom no cardiovascular disease or diabetes mellitus had been diagnosed. We evaluated blood pressure values, body weight, height, BMI, fasting glucose, total cholesterol, triglycerides, HDL and LDL in the serum of venous blood. The above-mentioned parameters were compared in women and men depending on BMI and age. It was demonstrated that the epidemiological situation of women in the analysed age group, regardless of the studied parameter and method of its evaluation, is much more favourable than that of men. We have demonstrated that evaluation of the analysed lipid parameters and blood pressure should be performed with consideration to gender and age. Otherwise conclusions may be obtained which are not satisfied by 75-95% of the population in a given age group. Obesity was highlighted as a factor triggering further lipid disturbances and blood pressure increase.

Refine search results

Immunometabolic role of leptin and adiponectin in atherosclerosis: relationships with cardiovascular complications in rheumatic diseases

Microarray technology in the study of genetic determinants of cardiovascular diseases

Addressing Cardiovascular Disease Risk in HungarianAmerican Populations: A Cultural Exploration of Transdisciplinary Health Promotion

Intervention for cardiovascular risk factors decreases adipocyte fatty acid-binding protein levels in males - a pilot study

Evaluation of selected lipid parameters and blood pressure in ethnically-homogenous population of middle-aged persons, depending on gender, age and body mass