Results of studies on birth control vaccines acomplished by many research groups within the WHO Special Programme of Research, Development and Research Training in Human Reproduction has been reviewed.The mostly investigated contraceptive vaccines contain human chorionic gonadotropin, and therefore structure, biological role and immunogenecity of the hormone were presented.Also vaccines obtained on teh basis of subunit beta of the human chorionic gonadotropin, its heterodimer with subunit beta of ovine lutropin or C-terminal peptide of beta subunit were described.Results of two phases of clinical trials with immuno-contraceptive vaccines were persented.The use of contraceptive vaccines for treatment of some trophoblastic tumors and the idea of using contraceptive recombinant vaccines were also mentioned.
There has been described molecular events towards preparation of for as (process known to be characterized by increased mobility of membrane components on sperm surface) and acrosomal reaction (fusion of spermatozoon plasmalemma with outer acrosomal membrane with following destruction of acrosomal compartment and enzyme release). These have been also described hypotheses concerning activity of exposed during acrosomal reaction receptors for and especially located on egg's . The role of acrosomal enzymes in penetration of zona pellucida by sperm as well as inhibition of enzymatic action were discussed in aspect of contraceptive potential.
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