Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl
Preferences help
Polish version English version Language
enabled [disable] Abstract
Number of results

Results found: 8

Number of results on page
first rewind previous Page / 1 next fast forward last

Search results

Search:
in the keywords:  CENTRAL NERVOUS SYSTEM
help Sort By:

help Limit search:
first rewind previous Page / 1 next fast forward last
1

Glutamate receptors in the central nervous system

100%
Kolonko A.
Postępy Higieny i Medycyny Doświadczalnej
|
1995
|
vol. 49
|
issue 6
719-731
EN
A lot of clinical processes following excessive stimulation of glutamate receptors seem to participate in pathophysiology of numerous acute and chronic neurologicla disorders.The whole of these reactions has been named as "glutamate cascade", because of the central role of glutamate in initiation and intensification of these processes.In this article, classification of different types of glutamate receptors and several hypotheses concerning mechanisms of glutamate neurotoxic activity are presented.A wide variety of neurological diseases, which etiologies are more or less connected with glutamate toxicity are discussed. At last, the future perspecives for treatment by drugs which action is though to be mediated through glutmate receptord are persented.
2

Neurotoxin induced modification of a cockroach central nervous system bioelectrical activity

80%
Stankiewicz M., Panek I., Grajpel B., Tegowska E., Kadziela W., Pelhate M.
Postępy Higieny i Medycyny Doświadczalnej
|
2000
|
vol. 54
|
issue 3
371-379
EN
Natural neurotoxins are promising molecules in the actual search for the development of alternative pest management since chemical insecticides pose unacceptable risks to the environment and to health. The aim of the article is to describe the application of two electrophysiological methods (double-oil-gap technique used on cockroach isolated giant axon and microelectrode technique used on cockroach neurosecretory DUM cells in situ) to study neurotoxin effects on insect nervous system function.
3

Interactions between endogenous opioid peptides and sex steroids in the central nervous system

80%
Bidzinska B., Jedrzejczuk D.
Postępy Higieny i Medycyny Doświadczalnej
|
1995
|
vol. 49
|
issue 4
523-530
EN
Gonadal steroids and beta-endorphin (beta-EP) (and probably other - EOP endogenous opioid peptides) play a role of the pivotal hormones involved in integration of several neurophysiological mechanisms.The reproductive system could be disturbed at hypothalmic level by interference of beta-EP witn GnRH secretion and/or at pituitary level with response of gonadotropes to GnRH.Gonadal steriods, through a feedback mechanism, may exert similar effect on hypothalmus and/or pituitary.The action of EOP on the hypothalmo-pituitary-gonadal axis may be influenced by physiological and pathological changes in gonadal steroids during puberty, menstrual cycle in females, menopause, in case of idiopathic delayed puberty, in patients with gonadal dysgenesis or after castration.EOP seems to be "gonadaostat" system that have a key role in the transmission of gonadal feedback signals to the brain.
4

Experimental and clinical aspects of neurotoxic effect of aluminium

70%
Nowak P., Brus R.
Postępy Higieny i Medycyny Doświadczalnej
|
1996
|
vol. 50
|
issue 6
621-633
EN
In the paper there were described some problems concerning influence of aluminium on central nervous system mainly. It was shown some aspects of neurotoxic action of aluminium in experimental studies and in some clinical disorders probability connected with intoxication of aluminium.
5
Content available remote

Injury induced dendritic plasticity in the mature central nervous system

70%
Macias M.
Acta Neurobiologiae Experimentalis
|
2008
|
vol. 68
|
issue 2
334-346
EN
Injury to the mature central nervous system (CNS) induces a series of transient changes leading not only to death of neurons, but also to spontaneous rearrangement of the affected network. One of such pro plastic events, detected following injury, is an increased level of neurotrophins. Neurotrophins are a family of proteins involved in survival and outgrowth processes. The other one, more difficult to observe, is a change in the complexity of the dendritic tree, causing arborization or pruning, depending on many circumstances: i.e. lesion etiology. Subsequent therapies like enriched environment or locomotor exercise bring about a functional improvement, which was found to further increase the neurotrophin level and induced additional arborization of dendrites. Another important consequence of damage to CNS connections is deafferentation, shown to induce a down regulation of outgrowth inhibitors. Their suppression in turn may facilitate dendritic plasticity. Taken together, these factors may contribute to enhanced plasticity in the injured mature CNS. Thus the proper use of endogenously increased plastic potential seems to be important for design and optimizing therapeutic strategies. Further investigation of mechanisms involved in switching on plasticity may help to improve on existing therapies and find new ways to obtain better recovery following injury.
6
Content available remote

Nitro l arginine attenuates SKF 38393 - induced oral activity in neonatal 6-hydroxydopamine-lesioned rats

70%
Brus R., Szkilnik R., Nowak P., Kostrzewa R. M.
|
EN
Nitric oxide (NO) in brain has been implicated in neuronal regulatory processes and in neuropathologies. Previously we showed that NO modified quinpirole induced yawning, a behavioral measure of dopamine (DA) D3 receptor activation in rats. The aim of this study was to characterize the effect of nitro L arginine methyl ester HCl (NAME) and L arginine HCl on reactivity of rats to the DA D1 receptor agonist SKF 38393 and DA D1 antagonist SCH 23390 in intact and neonatal6-hydroxydopamine (6 OHDA) lesioned rats (134 mug of base ICV at 3rd dayafter birth). L arginine HCl (300 mg/kg IP) increased the oral activity response in 6 OHDA lesioned rats, like SKF 38393, and induced catalepsy in intact control rats, like SCH 23390. In contrast, NAME had no effect on oral activity or catalepsy, but fully attenuated SKF 38393 induced oral activity. These findings indicate that L arginine HCl has no apparent effect at the DA D1receptor, but that NAME is effective in attenuating a DA D1 agonist - induced effect. Consequently NO may be an intracellular second mesenger for supersensitized receptors associated with DA D1 agonist induced oral activity.ity.
7
Content available remote

Central estrogen-like effect of genistein on growth hormone secretion in the ewe

61%
Misztal T., Wankowska M., Gorski K., Romanowicz K.
Acta Neurobiologiae Experimentalis
|
2007
|
vol. 67
|
issue 4
411-419
EN
The present study tested a hypothesis, whether plant-derived genistein influences the secretion of growth hormone (GH) in ewes, acting directly within the central nervous system (CNS). Starting six weeks after ovariectomy, ewes were infused intracerebroventricularly with genistein (n = 5) or 17beta-estradiol (n = 5), both in a total dose of 40 microg/400 microl/4 h, or with a vehicle (control, n = 5). All infusions were performed from 10:00 AM to 2:00 PM and blood samples were collected from 8:00 AM to 8:00 PM at 10-min intervals. Five genistein- and three vehicle-infused ewes were slaughtered the following morning. The plasma GH concentration was assayed by the radioimmunoassay method, and immunoreactivity of GH in the adenohypophysis was determined by immunohistochemistry. In genistein-infused ewes, mean plasma GH concentration was significantly higher during the whole period of infusion than the concomitant concentration in vehicle-infused ewes. However, examining data within group, GH secretion rose gradually, reaching a significant value during the second phase of genistein infusion. In 17beta-estradiol-infused animals, a significant increase in GH concentration was noted during the first two hours of the infusion, in comparison with vehicle-infused and also in comparison with genistein-infused ewes. Although a gradual increase in basic GH secretion continued in all treated groups during the afternoon and evening, mean plasma GH concentrations in genistein- and 17beta-estradiol-infused ewes were still significantly higher than in the vehicle-infused. The percentage of GH-positive cells in the adenohypophysis and the density of immunoreactive material in these cells decreased significantly in genistein-infused ewes, compared to the control, indicating diminished hormone storage. In conclusion, genistein as 17beta-estradiol, is an effective stimulator of GH secretion in ewes and may exert its effect at the level of the CNS.
8
Content available remote

Implications of the subtilisin/kexin-like precursor convertases in the development and function of nervous tissues

51%
Marcinkiewicz M., Seidah N. G., Chretien M.
Acta Neurobiologiae Experimentalis
|
1996
|
vol. 56
|
issue 1
287-298
EN
Furin, PC1, PC2 and PC5 represent mammalian convertases (PCs) found in endocrine, central and peripheral nervous tissues, which cleave a number of precursors at basic residues normally processed in vivo. Typical bonds cleaved by PCs include the pairs Lys-Arg, Arg-Arg and Arg-X-Lys/Arg-Arg. These cleavage sites have been detected following coexpression of each convertase in cell lines together with different precursors as models, including proopiomelanocortin (POMC), proinsulin and proNGF and proBDNF. The presence of PCs and different precursors was revealed by in situ hybridization or immunocytochemistry in cultured AtT-20 cells, in the developing CNS, pituitary, and pancreatic islets. In an experimental model of epilepsy in which epileptiform activities were provoked by kainic acid administration, we observed a similar transient expression of furin and PC1 as compared to that of NGF and BDNF. In conclusion, it is proposed that under different stimuli various precursors are activated by a unique cocktail of convertases, each of which either alone or in combination with others acts to process inactive precursors, and thereby playing an important role in development and in the plasticity of neuronal system.
first rewind previous Page / 1 next fast forward last
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.