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1

Cyclin-dependent kinases.From molecular biology to pathology

100%
Wolowiec D.
Postępy Higieny i Medycyny Doświadczalnej
|
1995
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vol. 49
|
issue 2
221-235
2

Role glyoxales and methyglyoxal in cell proliferation and differentiation

100%
Piskorska D., Grabowska-Bochenek R.
Postępy Higieny i Medycyny Doświadczalnej
|
1995
|
vol. 49
|
issue 3
433-444
EN
The glyoxalase system catalases the conversion of methylglyoxal (and other 2-ketoaldehydes) to D-latic acid via teh intrmediate S-D-lactoglutathione.It comprises two enzymes, glyoxalases I and glyoxalases II, and catalytic amount to reduced glutathione.Methylglyoxal inhibits cell growth, while the glyoxalase system by breaking down methylglyoxal may act as a promoter of cell growth.Inhibitors of glyoxalase may serve as possible therapeutic agents against cancer by virtue of their ability to elevate the level of methylglyoxal in the body.
3

Adrenal steroids act as inhibitory modulators of thyrofollicular cell morphology and proliferation in neonatal chicks (Gallus domesticus)

88%
Ganguli S., Bandyopadhyay R., Chakraborty S.
Folia Biologica
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2001
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vol. 49
|
issue 3-4
259-263
EN
In the present study the effects of adrenal corticoids, both natural and synthetic, namely cortisol and dexamethasone respectively, was observed on the thyroid gland cell morphology and proliferation in neonatal male chicks (Gallus domesticus). Cortisol was injected at a dose of 4 mg/100 g body weight and dexamethasone at a dose of 1 mg/100 g b.w. subcutaneously daily for fifteen consecutive days. The control birds were similarly injected with normal saline at a daily dose of 0.2 ml per bird for the same time period. The results indicated that both cortisol and dexamethasone caused a significant decrease in thyrofollicular cell height. On the contrary, a significant increase in the ratio of the follicular diameter to the number of nuclei per follicle i.e. D/N value was observed in both cortisol and dexamethasone treated chicks. It was also observed that both cortisol and dexamethasone induced suppression of mitotic activity, as evidenced from a significant decrease in mitotic percentage compared with the control chicks. The present authors? studies thus indicate that adrenal corticoids act as inhibitory modulators of thyroid follicular activity as regards karyomorphology and cell proliferation.
4

A role of protein kinase C isoforms in tumorigenicity and apoptotic cells death

88%
Rybczynska M., Ksiazek K., Kaczmarek J.
Postępy Higieny i Medycyny Doświadczalnej
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2000
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vol. 54
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issue 6
777-796
EN
Protein kinase C comprises a family of at least 13 distinct serine/threonine kinase isoenzymes that have important action in transmembrane signal transduction pathways and have been reported to regulate cell proliferation, differentiation, cell-to-cell interaction, cytoskeletal functions, gene transcription, apoptosis and drug resistance. The results of investigations show differential redistribution isozymes in each organs and their specyfic activity in determined diseases.
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