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Peptide loading of nascent MHC class i molecules

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Vukmanovic S., Lilic M., Santori F. R., Demaria S., Kulig K.
Archivum Immunologiae et Therapiae Experimentalis
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2001
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vol. 49
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issue 3
195-201
EN
A critical molecular interaction during assembly of the major histocompatibility complex (MHC) class I molecules takes place between the heavy chain and the transporter-associated with antigen-processing (TAP) complex. The recent mapping of regions of the heavy chain involved in the binding to TAP suggests a complex molecular interaction essential for the cell surface expression of the MHC class I. The advances made in understanding the TAP-MHC class I interaction are reviewed and discussed here.
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