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Retinal calcium-binding proteins. Their function and pathology

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Witkowska D., Gorczyca W.

Postępy Higieny i Medycyny Doświadczalnej

1997

vol. 51

issue 1

1-22

Calcium is involved in most cellular processes through calcium-binding proteins, belonging to the EF-hand superfamily. Recently new members of this family were found in the retina of vertebrates. Functions of these proteins and their relations to some neurological diseases are reviewed. Other EF-hand proteins found in the retina are also described.

Calcium signaling in the brain

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Heizmann C. W.

Calcium ions regulate many processes in the central nervous system via interaction with intracellular calcium-binding proteins. One class of these proteins shares a common structural motif, the EF-hand. A consensus amino acid sequence for this motif has aided the identification of many new members of this family. Some of these proteins, like parvalbumin, calbindin, and calretinin, proved to be useful neuronal markers for a variety of functional brain systems and their circuitries. Their major role is assumed to be buffering, transport of Ca?+, and regulation of various enzyme systems. Cellular degeneration is often accompanied by Ca?+ overload. It has been assumed that neurons containing certain intracellular Ca?+ - binding proteins may have a greater capacity tu buffer Ca?+ and therefore would be more resistant to degeneration.

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1 Acta Neurobiologiae Experimentalis

1 Postępy Higieny i Medycyny Doświadczalnej

1 1997

1 1993

1 Gorczyca W.

1 Heizmann C. W.

1 Witkowska D.

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Retinal calcium-binding proteins. Their function and pathology

Calcium signaling in the brain