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Gene expression in learning processes

100%

Kaczmarek L.

It has repeatedly been shown that long-term memory formation involves neuronal gene expression. In this article several different roles for neuronal gene function in a context of learning are considered: maintenance of neural functioning, replenishment of cellular elements that are exhausted in response to massive neuronal stimulation accompanying behavioral training, maintenance of the plastically reorganized neuronal connections, and finally integration of information at the level of transcription factor-promoter interaction. It is strongly advocated that only careful scrutiny of learning-related gene expression phenomena may aid in understanding of the complex learning process.

Inducing gene expression in barrel cortex - focus on immediate early genes

86%

Filipkowski R. K.

Acta Neurobiologiae Experimentalis

2000

vol. 60

issue 3

411-418

Using only their vibrissae, rats and mice are able to recognize and differentiate surfaces not distinguishable by primates using their fingertips. It has been shown that sensory stimulation elicits the expression of immediate-early genes (IEG), e.g., c-fos and zif268, in the sensory cortex of rats and mice. Though most of these findings come from visual system, mice and rats rely more on their vibrissal system which also offers many advantages for designing precise and precisely controlled experiments. In this review, new models for the selective and simple stimulation of vibrissae are presented and discussed. The data demonstrating IEG expression in the vibrissal system is also reviewed.

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2 Acta Neurobiologiae Experimentalis

2 2000

1 Filipkowski R. K.

1 Kaczmarek L.

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Gene expression in learning processes

Inducing gene expression in barrel cortex - focus on immediate early genes