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Features of heart rate variability in breast cancer survivors with various types of attitude to the disease

100%
Prystupa E., Odynets T., Briskin Y., Svistelnyk I.
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2018
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vol. 32
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issue 3
5-9
EN
Introduction Surgical treatment and radiotherapy can prolong the life expectancy of women with breast cancer but also might have side effects on heart rate variability. Currently breast cancer treatment has contributed to significant improvements in survival rate, but negative effects on the psycho-emotional state and functionality of the autonomic nervous system of these interventions in women is high. We aimed to investigate the heart rate variability features in breast cancer survivors who have varied attitudes towards the disease. Material and methods Heart rate variability analysis, determination of various attitudes towards the disease, and mathematical statistical methods. The survey of 110 breast cancer survivors was conducted utilizing Type of Attitude Toward The Disease questionnaire. The women were executed radical mastectomy and adjuvant radiation treatment for breast cancer. Patients aged between 56 and 60 years. Results The results of our study showed that patients with a rational type of attitude towards disease had statistically (p<0.05) better parameters of heart rate variability. Values of standard deviation of the N-N interval, root mean square of successive differences, total power, high-frequency range, and stress index were much better in patients with rational type of attitude as compared with the women who had intrapsychic and interpsychic attitudes. Conclusions These data show that identified features of various attitudes towards the disease in breast cancer survivors clarify the necessity for particular attention to their heart rate variability parameters.
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Vanadium rutin complex sensitizes breast cancer cells via modulation of p53/Bax/Bcl2/VEGF correlated with apoptotic events

100%
Haifeng Z., Yinghou W., Dan L., Xiuqing S., Furong W.
Acta Poloniae Pharmaceutica - Drug Research
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2020
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vol. 77
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issue 1
89-98
EN
In pursuit of a novel approach in breast cancer therapy, we explored the ability of vanadium rutin complex to eradicate cancer by efficiently targeting various apoptotic pathways on human breast cancer cell lines. We provide direct proof of the chemotherapeutic potential of vanadium rutin complex by activating p-53 dependent intrinsic apoptosis and modulating the VEGF pathways. The complex was also capable of binding and cleaving CT-DNA at different concentration. The complex was able to inhibit cell viability at 100 and 150 µM doses in both MCF7 and MDA-MB-231 cells. Furthermore, the complex successfully initiated apoptosis in both cell lines by activating the p53 dependant intrinsic apoptotic pathway. In-vitro studies also established that the complex modulated p53, Bax, Bcl2 and VEGF expressions and induced DNA fragmentation in both the cell lines.
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Risk factors for breast cancer-related upper extremity lymphedema: Is immediate autologous breast reconstruction one of them?

86%
Gur A., Unal B., Ahrendt G., Gimbel M., Kayiran O., Johnson R., Bonaventura M., Soran A.
Open Medicine
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2009
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vol. 4
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issue 1
65-70
EN
Breast cancer related upper extremity lymphedema (BCRL) reduces the quality of life of those who have had surgery for breast cancer. The aim of this study is to evaluate the risk factors for BCRL and determine whether immediate autologous tissue breast reconstruction is one of them. A case control study was conducted comparing patients with BCRL (n=97) to surgically treated breast cancer patients without BCRL (control, n=126). The groups were matched for age, type of breast surgery and radiation therapy. Postoperative upper extremity infection, body mass index (BMI), occupation (level of hand-use), and immediate autologous tissue breast reconstruction were investigated as a risk factor of BCRL. Mastectomy was performed on 47.6 % (n=60) and 37.2% (n=36) of patients in the control and the BCRL groups, respectively. Eight patients (13.3%) had immediate autologous tissue breast reconstruction in the control mastectomy group. Six of 36 BCRL patients (16.7%) underwent mastectomy with immediate autologous tissue breast reconstruction. There was no significant difference between groups with respect to incidence or method of immediate reconstruction (p=0.65). Patient occupation (level of hand use) was found to be positively correlated to development of BCRL (p=0.0001). Upper extremity infection rate was 22.7% in the BCRL group and 4.0% in the controls (p=0.0001). The mean BMI in the control and BCRL groups 26.8 kg/m2 and 29.1kg/m2, respectively (p=0.003). In conclusion, in this study characteristics positively associated with development of BCRL included occupation, infection, and increased BMI. Immediate reconstruction of the breast was not found as a risk factor for BCRL. However larger studies are needed, to further evaluate the effect of breast reconstruction on BCRL.
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