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Accuracy of non-invasive intracranial pressure measurement

100%
Seddighi A., Zadeh A., Seddighi A., Zali A.
Open Medicine
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2012
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vol. 7
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issue 2
169-175
EN
Non-invasive measurement of intracranial pressure (ICP) reduces the complications and cost for both patient and health care systems. Improvement of non-invasive methods has led to development of systems for reproducing continuous, real-time non-invasive ICP signals. So far, non-invasive methods have been tailored for the patients with head trauma. We have used Schmidt’s auto-adaptive method to assess the accuracy of this method for patients after surgery for supratentorial brain tumors. Data from forty patients with the diagnosis of brain tumor operated from 2008 to 2010 were used to estimate the accuracy of Schmidt’s method in our patients. We obtained the model parameters from 30 recordings. We determined the ICP wave form for the remaining patients by both invasive and non-invasive techniques. In the test group, by invasive method, the mean ICP±2SD was 17.1 ± 6.6 mmHg and using non-invasive method, the mean ICP ± 2SD was 16.5 ± 5.4 mmHg. The calculated error was 4.6 mmHg using root mean square errors. The average Pearson correlation between the estimated and real waveforms was 0.92. We believe that application of this method is acceptable for post-operative assessment of ICP in brain tumor patients.
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Roles and Mechanisms of Docosahexaenoic Acid (DHA) in Neurodevelopment, Neuronal Functions, Learning and Memory

86%
Evbuomwan S. A., Omotosho O. E., Mgbojikwe I.
World News of Natural Sciences
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2022
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vol. 40
104-119
EN
Docosahexaenoic acid (DHA) is an omega-3 fatty acid which is a major constituent of the brain, retina and skin in terms of structure. DHA can be produced from the metabolic synthesis of alpha linolenic acid (ALA) or gotten from breast milk, fatty fishes, or oil from algae. Studies have shown that DHA is an essential nutrient for normal functioning of the brain. It is the major omega-3 fatty acid present in brain tissues and is known to have effects on neurotransmitters, synaptic transmission, and signal transduction. Also, certain DHA metabolites are biologically active molecules that protect the tissues from oxidative injury and stress. DHA is also known to carry out important membrane neuronal functions such as Phospholipid synthesis, membrane fluidity, neuronal survival, regulation of gene expression and modulation of enzyme activity in the brain. Therefore, DHA needs to be taken at developmental stages of human life such as period of pregnancy, lactation and even childhood for proper development and functioning of the brain.
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Perspectives of use of bone marrow cells in future therapy of brain diseases

72%
Opydo-Chanek M., Pasiut S.
Medical Rehabilitation
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2007
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vol. 11(1)
31-39
EN
Medical problems associated with the increasing number of patients suffering from brain diseases have resulted in a constant search for effective therapeutics. Considering the complicated pathological processes occurring in diseases of the central nervous system and the limited capability of the neural tissue to regenerate, therapy of neurological diseases is extremely difficult. The lack of efficient medical treatment results in complex problems associated with rehabilitation and thus in functional disturbances, which prevent patients from restoring their independence and returning to complete, also professional, activity, Cell therapy has recently been considered as a possible approach in the treatment of brain diseases. Its aim is to supply pathologically changed brain tissue with factors promoting regeneration and with cells that may replace the damaged ones. Bone marrow cells have become a potential source of cells in this type of therapy. Bone marrow contains at least two major kinds of stem cells: haematopoietic stem cells, which give rise to the blood cells and mesenchymal stem cells, which can differentiate into cells of mesenchymal lineage and produce an array of growth factors essential for repair. The review presents the achievements of studies on use of bone marrow cells in the therapy of various brain diseases of traumatic or neurodegenerative aetiology.
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