Search results

Search:
in the keywords: Bleomycin

Sort By:

Limit search:

The Efficacy of Various Management Options for Malignant Pleural Effusions

100%

Kacprzak G., Kołodziej J.

Polish Journal of Surgery

2007

vol. 79

issue 3

196-208

Malignant pleural effusion (MPE) may be the first manifestation of the neoplastic disease or its complication.The aim of the study was determining the most effective management, comparison of the efficacy of various therapeutic options, evaluation of treatment results.Material and methods. Between 1996 and 2003, 150 patients were treated in the Wrocław Thoracic Surgery Centre. Lung cancer was diagnosed in 61 (40.7%), other malignancy in 82 (54.7%), primary focus was not established in 7 (4.7%) patients. There were following groups. Group I (n=39): patients who underwent pleurodesis with Bleomycin (60 mg), group II (n=36) - Doxycylin (1 g or 0,5 g), group III (n=52) - Talc (4 g), group IV (n=12) - politherapy, group V (n=11) - other patients.Results. Patients from group I - IV were undergone statistical analysis. This group was divided into subgroup A (n=24, patients who died within first month) and subgroup B (n=115, who lived longer). In subgroup A total remission was achieved in I - 100%, in II - 70%, in III - 100%. The worst results were obtained in group II, but there weren't SSD between groups (p>0,05). In subgroup B total remission was analyzed after 1, 3, 6, 9 months. Total remission after 9 months was achieved in I - 85,2%, in II - 69,2%, in III - 98%, in IV - 91,7%. SSD occurred between groups I and III (p=0,0327), II and III (p<0.001). Median mean rate survival was in I - 239, in II - 232, in III - 267, in IV - 207 days (p>0,05). Drainage complications and signs effect were analyzed.Conclusions. The best results were achieved after using Talc. In instance of difficulties of inhibition MPE we should apply politherapy. There weren't SSD in survival length between groups. The most common signs effect was pain, which occurred more frequent after instillation of Doxycyline and Talc than Bleomycin and fever which occurred the most frequent after instillation Talc and after politherapy

Drainage of the Pleural Cavity and Chemical Pleurodesis for Malignant Pleural Effusion - Comparison of Bleomycin and Doxycycline

100%

Kacprzak G., Kołodziej J.

Polish Journal of Surgery

2008

vol. 80

issue 4

173-183

Malignant pleural effusion (MPE) may be an indication for palliative treatment to improve the quality of life and allow patients to leave the hospital. The most common treatment for MPE is drainage of the pleural cavity followed chemical pleurodesis.The aim of the study was to compare the efficacy of Bleomycin and Doxycycline for pleurodesis.Material and methods. Between 1996 and 2006, 105 patients (aged 30-84) were treated in the Wrocław Thoracic Surgery Centre for MPE using drainage of the pleural cavity followed by Bleomycin or Doxycycline for chemical pleurodesis. Lung cancer was diagnosed in 53 patients (49.5%), other malignancy in 49 patients (46.7%), and the primary focus was not established in 4 (3.8%) patients. Patients were divided into two groups: group I (n=56) consisted of patients who underwent pleurodesis with Bleomycin (60 mg), and group II (n=49) consisted of patients treated with Doxycycline (1 g or 0,5 g). Patients were divided into two subgroups. Subgroup A (n=31) included patients who died within the first month, and subgroup B (n=74) included patients who lived longer.Results. In subgroup A, total remission was achieved in 100% of group I - patients and 78.6% of group II - patients, respectively. There were no statistically significant differences (SSDs) between groups (p>0.05). In subgroup B, remission was analyzed after 1, 3, 6, and 9 months. Total remission after 9 months was achieved in 84.6% and 77.1% of patients in groups I and II, respectively. There were no statistical differences between groups. The median mean rate survival in groups I and II was 251 and 242 days, respectively (p>0.05). Drainage complications and side effects were analyzed.Conclusions. Better results were achieved following the use of Bleomycin than Doxycycline, but there were no SSDs between groups, nor were three any SSDs in survival length between groups. The most common side effect was pain, which occurred more frequently after treatment with Doxycycline than Bleomycin.

Refine search results

2 Polish Journal of Surgery

1 2008

1 2007

2 Kacprzak G.

2 Kołodziej J.

Search results

The Efficacy of Various Management Options for Malignant Pleural Effusions

Drainage of the Pleural Cavity and Chemical Pleurodesis for Malignant Pleural Effusion - Comparison of Bleomycin and Doxycycline