Search results

1

Effect of tetracyclines on bone metabolism

100%

Fowarczna J.

Postępy Higieny i Medycyny Doświadczalnej

|

2003

|

vol. 57

|

issue 2

185-198

EN

Tetracyclines, antibiotics widely used in medical practice, have many effects independent of their antimicrobial activity, among others they exert anti-collagenolytic activity. The paper presents a review of literature concerning the effects of tetracyclines on the skeletal system.

2

Calcium deficiency as one of the risk factors for osteoporosis

100%

Brzoska M., Moniuszko-Jakoniuk J.

Postępy Higieny i Medycyny Doświadczalnej

|

1997

|

vol. 51

|

issue 1

55-74

EN

An adequate calcium intake is important to attain peak bone mass and to oppose that component of age-related bone loss. Calcium deficiency is one of the risk factors for osteoporosis. Calcium supplements is particularly important for preventing bone loss and fractures.

3

Ectopic bone formation after treatment with colchicine

88%

Tworek K., Solak K., Janeczek A., Niedzwiedzki T., Tabarowski Z., Dabrowski Z., Schoutens A., Tworek S.

Folia Biologica

|

2010

|

vol. 58

|

issue 1-2

125-133

EN

We followed changes occurring within bone tissue and marrow cells during the process of colchicine-induced ectopic bone development and its resorption inside the marrow cavity of the rat tibia. To stimulate ectopic bone formation male Wistar rats were i.p injected with 0.5 or 1mg/kg b.w. of colchicine orwith a 100 Fg intra-bone injection.Not all subjects responded to colchicine with ectopic bone formation in the marrow cavity, even among individuals belonging to the same strain. The kind of response in a given animal depended on the dose and site of colchicine administration. During 10 days of the experiment an increase in the occurrence of micronuclei in the polychromatic erythrocytes residing in the bone marrow (even 40-fold) was observed, indicating high genotoxicity of colchicine (at a dose of 1 mg/kg b.w. i.p. or 100 Fg intra-bone injection). An increase in the frequency of emperipolesis in megakaryocytes between the 4th and 8th days of the experiment was caused by the toxic action of colchicine and may indicate the labilisation of cell membranes and microtubule depolymerisation.

4

Detecting a deletion in the coding region of the bovine bone morphogenetic protein 15 gene (BMP15)

75%

Zhang L.-P., Gan Q.-F., Zhang X.-H., Li H.-D., Hou G.-Y., Li Y.-J., Gao X., Ren H.-Y., Chen J. B., Xu S.-Z.

Journal of Applied Genetics

|

2009

|

vol. 50

|

issue 2

145-148

EN

The aim of this study was to detect polymorphism in the bovine bone morphogenetic protein 15 (BMP15) gene. On the basis of PCR-SSCP and DNA sequencing, a 4-bp deletion was identified in the coding region of the gene. Sequence analysis revealed that the deletion altered the reading frame and introduced a stop codon at position 264. Eight breeds (Luxi, Qinchuan, Nanyang, Jinnan, Bohai Black, Menggolian, Holstein, and Simmental) were genotyped by PCR-SSCP. No cows homozygous for this mutation were observed in these breeds. Heterozygous cows were detected in Luxi, Qinchuan, Nanyang, Jinnan and Bohai Black cattle. Fecundity was not increased in heterozygous individuals.

Refine search results

2 Postępy Higieny i Medycyny Doświadczalnej

1 Folia Biologica

1 Journal of Applied Genetics

1 2010

1 2009

1 2003

1 1997

1 Brzoska M.

1 Chen J. B.

1 Dabrowski Z.

1 Fowarczna J.

1 Gan Q.-F.

1 Gao X.

1 Hou G.-Y.

1 Janeczek A.

1 Li H.-D.

1 Li Y.-J.

1 Moniuszko-Jakoniuk J.

1 Niedzwiedzki T.

1 Ren H.-Y.

1 Schoutens A.

1 Solak K.

1 Tabarowski Z.

1 Tworek K.

1 Tworek S.

1 Xu S.-Z.

1 Zhang L.-P.

1 Zhang X.-H.

Effect of tetracyclines on bone metabolism

Calcium deficiency as one of the risk factors for osteoporosis

Ectopic bone formation after treatment with colchicine

Detecting a deletion in the coding region of the bovine bone morphogenetic protein 15 gene (BMP15)