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Oxidative damage to DNA and antioxidant status in aging and age-related diseases

100%
Olinski R., Siomek A., Rozalski R., Gackowski D., Foksinski M., Guz J., Dziaman T., Szpila A., Tudek B.
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2007
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vol. 54
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issue 1
11-26
EN
Aging is a complex process involving morphologic and biochemical changes in single cells and in the whole organism. One of the most popular explanations of how aging occurs at the molecular level is the oxidative stress hypothesis. Oxidative stress leads in many cases to an age-dependent increase in the cellular level of oxidatively modified macromolecules including DNA, and it is this increase which has been linked to various pathological conditions, such as aging, carcinogenesis, neurodegenerative and cardiovascular diseases. It is, however, possible that a number of short-comings associated with gaps in our knowledge may be responsible for the failure to produce definite results when applied to understanding the role of DNA damage in aging and age-related diseases.
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Comparison of Different Wavelength Propagations over Few-Mode Fiber based on Space Division Multiplexing in Conjunction with Electrical Equalization

100%
Al-Dawoodi A., Fareed A., Masuda T., Ghazi A., Fakhrudeen A. M., Aljunid S. A., Idrus S. Z. S., Amphawan A.
International Journal of Electronics and Telecommunications
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2019
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vol. 65
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issue 1
3
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Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease

84%
Krwawicz J., Arczewska K. D., Speina E., Maciejewska A., Grzesiuk E.
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2007
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vol. 54
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issue 3
413-434
EN
Base excision repair (BER) pathway executed by a complex network of proteins is the major system responsible for the removal of damaged DNA bases and repair of DNA single strand breaks (SSBs) generated by environmental agents, such as certain cancer therapies, or arising spontaneously during cellular metabolism. Both modified DNA bases and SSBs with ends other than 3'-OH and 5'-P are repaired either by replacement of a single or of more nucleotides in the processes called short-patch BER (SP-BER) or long-patch BER (LP-BER), respectively. In contrast to Escherichia coli cells, in human ones, the two BER sub-pathways are operated by different sets of proteins. In this review the selection between SP- and LP-BER and mutations in BER and end-processors genes and their contribution to bacterial mutagenesis and human diseases are considered.
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