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1

The biological role and function of basement membranes. Filter barrier of glomerulus

100%
Steciwko A., Sapilak B. J.
Postępy Higieny i Medycyny Doświadczalnej
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2000
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vol. 54
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issue 2
199-211
EN
This article presents the latest information about biological functions of ba sement membranes. We drew a special attention to glomerular basement membrane. Besides, this article contains information about filter barrier and interactions between basal membranes and tissues.
2

Components and three-dimensional conformation of basement membrane

100%
Sapilak B. J., Steciwko A.
|
EN
This article presents the latest information about biological functions of basement membranes. It describes all important basement membranes? components and their structure. Schemes showing modular sequence of collagens, nidogen, llaminins and other polypeptides and also structural model of basement membranes were included.
3

New collagenous proteins: FACITs, transmembrane collagens and multiplexins

75%
Gogiel T., Bankowski E.
Postępy Higieny i Medycyny Doświadczalnej
|
2001
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vol. 55
|
issue 1
133-156
EN
Collagens are the main components of the extracellular matrix and they constitute about 30% of total body protein. Each collagen molecule consists of three polypeptide chains that intertwine in one or more places into triple helical domains, a very rare structure in other proteins. Nineteen collagen types have been described to date and those forming banded fibrils are the most abundant. In the last decade new collagenous proteins were discovered that have been classified into three distinct groups: fibril-associated collagens with interrupted triple helices (FACITs), transmembrane collagens and multiplexins. FACITs appear to connect collagen fibrils to other matrix components or cells. Transmembrane collagens have intracellular domains and they participate in cell adhesion and probably in signal transduction. Multiplexins are situated mainly in basement membranes and contain sequences, which demonstrate features of angiogenesis inhibitors reducing the growth of neoplasmatic tumours.
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